tailieunhanh - The inflammatory mediators and sepsis

The occurrence, severity and mortality rates in human sepsis are increasing worldwide despite an increasing numerous clinical and experimental studies investigating sepsis. Sepsis is a severe clinical syndrome associated to the host response to infection. An auto-amplifying cytokine production: the cytokine storm is the main reason leading to the severity of infections. Cytokines are a large group of protein molecules that control the immune response during the inflammation in the body. | 2018 7 3 1763-1776 EXCELLENT PUBLISHERS International Journal of Current Microbiology and Applied Sciences ISSN 2319-7706 Volume 7 Number 03 2018 Journal homepage http Review Article https The Inflammatory Mediators and Sepsis Adel M. Almawash Department of Botany and Microbiology College of Sciences King Saud University Riyadh Saudi Arabia Corresponding author ABSTRACT Keywords Inflammatory mediators and Sepsis Procalcitonin Article Info Accepted 16 February 2018 Available Online 10 March 2018 The occurrence severity and mortality rates in human sepsis are increasing worldwide despite an increasing numerous clinical and experimental studies investigating sepsis. Sepsis is a severe clinical syndrome associated to the host response to infection. An auto-amplifying cytokine production the cytokine storm is the main reason leading to the severity of infections. Cytokines are a large group of protein molecules that control the immune response during the inflammation in the body. Although advancing in our knowledge about the processes that activate release great amount of cytokines these understandings could not translate yet into effective treatments and diagnosis. This review aims to summarize our knowledge about most important inflammatory mediators in sepsis pathophysiology. Introduction Annually many of patients are deaths due to infection diseases. Sepsis is leading causes of death every year with at least 19 million cases especially in low- and middle-income countries Adhikari et al. 2010 . The occurrence severity and mortality rates in sepsis in humans are increasing globally although the availability of immediate fluid resuscitation antibiotics and improvement in intensive care unit sepsis patients can rapidly deteriorate into septic shock leading to multiple organ failure and death Hotchkiss and Karl 2003 . In the first days of the early acute inflammatory phase some sepsis .