tailieunhanh - Palmitate induced regulation of PPARγ via PGC1α: A mechanism for lipid accumulation in the liver in non-alcoholic fatty liver disease

The aim was to examine the effect of free fatty acids on the regulation of PPARγ-PGC1α pathway, and the effect of PPARγ/PGC1α in NAFLD. The mRNA and protein expression of PGC1α and phospho/total PPARγ were examined in Huh7 cells after the palmitate/oleate treatment with/without the transfection with siRNA against PGC1a. | Palmitate induced regulation of PPARγ via PGC1α: A mechanism for lipid accumulation in the liver in non-alcoholic fatty liver disease