tailieunhanh - Effects of acidification and alkalinization on the lipid emulsion-mediated reversal of toxic dose levobupi-vacaine-induced vasodilation in the isolated rat aorta

The goal of this in vitro study was to examine the effects of pre-acidification and pre-akalinization on the lipid emulsion-mediated reversal of toxic dose levobupivacaine-induced vasodilation in isolated rat aorta. Isolated aortic rings with and without the nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester (L-NAME) were exposed to four types of Krebs solution (pH , , , and ), followed by the addition of 60 mM potassium chloride. | Effects of acidification and alkalinization on the lipid emulsion-mediated reversal of toxic dose levobupi-vacaine-induced vasodilation in the isolated rat aorta