tailieunhanh - Regulation of DMT1 on bone microstructure in type 2 diabetes

Diabetic osteoporosis is gradually attracted people's attention. However, the process of bone microstructure changes in diabetic patients, and the exact mechanism of osteoblast iron overload are unclear. | Int. J. Med. Sci. 2015 Vol. 12 441 IVYSPRING ĩtttonmtìnníií n-C OM ơrdrnf ĩriữnrữc INTERNATIONAL PUBLISHER international journal Oj jVLeaicai Sciences 2015 12 5 441-449. doi Research Paper Regulation of DMT1 on Bone Microstructure in Type 2 Diabetes Wei-Lin Zhangt Hong-Zheng Mengt Mao-Wei YangE Department of Orthopedics the First Hospital of China Medical University Shenyang Liaoning China t These authors contribute equally to this work. El Corresponding author Mao-Wei Yang Department of Orthopedics The First Hospital of China Medical University 155 North Nanjing Street Shenyang Liaoning 110001 China. E-mail ymw69@ FAX 86 24 83283360 Phone 86 24 83283360 2015 Ivyspring International Publisher. Reproduction is permitted for personal noncommercial use provided that the article is in whole unmodified and properly cited. See http terms for terms and conditions. Received Accepted Published Abstract Diabetic osteoporosis is gradually attracted people s attention. However the process of bone microstructure changes in diabetic patients and the exact mechanism of osteoblast iron overload are unclear. Therefore the present study aimed to explore the function of DMT1 in the pathological process of diabetic osteoporosis. We build the type two diabetes osteoporosis models with SD rats and Belgrade rats respectively. Difference expression of DMT1 was detected by using the method of immunohistochemistry and western blotting. Detection of bone microstructure and biomechanics and iron content for each group of samples. We found that DMT1 expression in type 2 diabetic rats was higher than that in normal rats. The bone biomechanical indices and bone microstructure in the rat model deficient in DMT1 was significantly better than that in the normal diabetic model. The loss of DMT1 can reduce the content of iron in bone. These findings indicate that DMT1 expression was enhanced in the bone tissue of type