tailieunhanh - A study on paracetamol cardiotoxicity

Sri Lanka has a high suicide rate, with more than 40 % of poisoning admissions due to overdose of drugs with Paracetamol being the commonest. Data regarding cardiotoxicity to paracetamol is very minimal though hepatotoxicity following poisoning is well studied. Paracetamol cardiotoxicity has rarely been clinically significant and may have well been overlooked. | Ralapanawa et al. BMC Pharmacology and Toxicology 2016 17 30 DOI s40360-016-0073-x BMC Pharmacology and Toxicology RESEARCH ARTICLE Open Access A study on paracetamol cardiotoxicity Udaya Ralapanawa1 Kushalee Poornima Jayawickreme1 Ekanayake Mudiyanselage Madhushanka Ekanayake1 and A. M. S. Dhammika Menike Dissanayake2 Abstract Background Sri Lanka has a high suicide rate with more than 40 of poisoning admissions due to overdose of drugs with Paracetamol being the commonest. Data regarding cardiotoxicity to paracetamol is very minimal though hepatotoxicity following poisoning is well studied. Paracetamol cardiotoxicity has rarely been clinically significant and may have well been overlooked. The possibility that paracetamol overdose might be directly cardiotoxic has been the subject of a few reports. Unexplained deaths and electrocardiographic changes associated with paracetamol poisoning have also been reported in which cardiac origin cannot be clearly ruled out. Although some studies state that paracetamol poisoning has no direct cardiotoxic effect electrocardiographic changes due to metabolic derangement of hepatotoxicity have been shown in certain studies. Thus we conducted this study to assess in detail the cardiotoxic effect of paracetamol poisoning. Methods This is a cross sectional descriptive study done on those with confirmed paracetamol poisoning. Serum paracetamol levels Electrocardiogram Echocardiogram troponin I and other basic investigations were done. Results Paracetamol ingestion is more common among teenagers and the young population in Sri Lanka. Although several cases of paracetamol poisoning induced cardiotoxicity has been described in the past this study demonstrated no electrocardiographic echocardiographic or cardiac biomarkers changes of myocardial toxicity. Conclusion Though literature review support cardiotoxicity following paracetamol poisoning our study does not provide enough evidence for this. Continuous cardiac monitoring .

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