tailieunhanh - Lecture Chemical process control - Chapter 24

a | Chapter 24 Dynamics and Control of Biological Systems Chapter 24 addresses a variety of analysis problems in the field of biosystems Systems Biology Gene Regulation Circadian Rhythm Clock Network Signal Transduction Networks Chemotaxis Insulin Mediated Glucose Uptake Simple Phosphorylation Transduction Cascade 1 Chapter 24 What is Systems Biology WTEC Benchmark Study 2005 M. Cassman A. Arkin F. Doyle F. Katagiri D. Lauffenburger C. Stokes also Nature Dec 22 2005 Primary Definition The understanding of biological network behavior through the application of modeling and simulation tightly linked to experiment Related Ideas - Identification and validation of networks - Creation of appropriate datasets - Development of tools for data acquisition and software Motivation Phenotype is governed by the behavior of networks rather than the operation of single genes. Understanding the dynamics of even the simplest biological networks requires the application of modeling and simulation. 2 Chapter 24 Folded Protein Figure Feedback and feedforward control loops that regulate heat shock in bacteria modified from El-Samad et al. 2006 .