tailieunhanh - CD4+ CD25+ cells in type 1 diabetic patients with other autoimmune manifestations

The existence of multiple autoimmune disorders in diabetics may indicate underlying primary defects of immune regulation. The study aims at estimation of defects of CD4+ CD25+high cells among diabetic children with multiple autoimmune manifestations, and identification of disease characteristics in those children. Twenty-two cases with type 1 diabetes associated with other autoimmune diseases were recruited from the Diabetic Endocrine and Metabolic Pediatric Unit (DEMPU), Cairo University along with twenty-one normal subjects matched for age and sex as a control group. Their anthropometric measurements, diabetic profiles and glycemic control were recorded. Laboratory investigations included complete blood picture, glycosylated hemoglobin, antithyroid antibodies, celiac antibody panel and inflammatory bowel disease markers when indicated. Flow cytometric analysis of T-cell subpopulation was performed using antiCD3, anti-CD4, anti-CD8, anti-CD25 monoclonal antibodies. Three cases revealed a proportion of CD4+ CD25+high below and one case had zero counts. However, this observation did not mount to a significant statistical difference between the case and control groups neither in percentage nor absolute numbers. Significant statistical differences were observed between the case and the control groups regarding their height, weight centiles, as well as hemoglobin percentage, white cell counts and the absolute lymphocytic counts. We concluded that, derangements of CD4+ CD25+high cells may exist among diabetic children with multiple autoimmune manifestations indicating defects of immune controllers. | CD4+ CD25+ cells in type 1 diabetic patients with other autoimmune manifestations

• Y khoa - Dược
• Type1 diabetes mellitus
• T regulatory cells
• Autoimmune manifestations
• Percentage nor absolute numbers
• Diabetic children
• Preventable Patient
• Danish Patient
• Diagnostic Tool
• Oxytocin and Myometrial
• Contractility in Labor
• Operative Vaginal Deliveries
• Psychological Impact
• Chronic Renal Failure
• Renal Replacement
• Uremic Diabetic
• Patients – Experience
• Republic of Macedonia
• BMC Pediatrics
• Fatty liver
• Hepatic glycogenosis
• Type 1 diabetes
• Diabetes mellitus