tailieunhanh - pH-dependent solubility and dissolution behavior of carvedilol — Case example of a weakly basic BCS class II drug
The objective of this study was to investigate the pH-dependent solubility and dissolution of weakly basic Biopharmaceutical Classification Systems (BCS) class II drugs, characterized by low solubility and high permeability, using carvedilol, a weak base with a pKa value of , as a model drug. A series of solubility and in vitro dissolution studies was carried out using media that simulate the gastric and intestinal fluids and cover the physiological pH range of the GI from to . The effect of ionic strength, buffer capacity, and buffer species of the dissolution media on the solubility and dissolution behavior of carvedilol was also investigated. | pH-dependent solubility and dissolution behavior of carvedilol Case example of a weakly basic BCS class II drug
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