tailieunhanh - Development of solid self-emulsifying formulation for improving the oral bioavailability of erlotinib

To improve the solubility and oral bioavailability of erlotinib, a poorly water-soluble anticancer drug, solid self-emulsifying drug delivery system (SEDDS) was developed using solid inert carriers such as dextran 40 and Aerosil® 200 (colloidal silica). The preliminary solubility of erlotinib in various oils, surfactants, and co-surfactants was determined. Labrafil M2125CS, Labrasol, and Transcutol HP were chosen as the oil, surfactant, and co-surfactant, respectively, for preparation of the SEDDS formulations. The ternary phase diagram was evaluated to show the self-emulsifying area. The formulations were optimized using the droplet size and polydispersity index (PDI) of the resultant emulsions. Then, the optimized formulation containing 5% Labrafil M2125CS, 65% Labrasol, and 30% Transcutol was spray dried with dextran or Aerosil® and characterized for surface morphology, crystallinity, and pharmacokinetics in rats. Powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) exhibited the amorphous form or molecular dispersion of erlotinib in the formulations. | Development of solid self-emulsifying formulation for improving the oral bioavailability of erlotinib

• Y khoa - Dược
• Spray drying
• Oral bioavailability of erlotinib
• Solid self emulsifying formulation
• Pharmacokinetics in rats
• Differential scanning calorimetry
• Drying method
• Sun drying
• Solar drying
• Freeze drying
• Drying techniques in food processing
• Optimization of maltodextrin in spray drying process
• Carrageenan gum concentration added in spray drying process
• Pouzolzia zeylanica extract
• Response surface methodology
• Changes of total polyphenolics and vitamin C
• Acerola during storage and spray drying process
• Acerola during storage
• Spray drying process
• Vitamin C and total polyphenolics
• CFD simulation
• Single droplet drying model
• Characteristic drying curve model
• Skim milk
• Acerola fruit
• Vitamin C
• Natural oxidants occurring in plants
• Drying carrier
• Total polyphenolics
• Black shallot
• Dried powder
• Black shallot extract
• Compression index
• High speed centrifugal spray
• Tạp chí khoa học
• Tạp chí y dược
• Y dược quân sự
• Curcumin solid dispersion
• Spray drying method
• Experimental design
• Tạp chí Khoa học công nghệ và Thực phẩm
• Microencapsulation of lactobacillus fermentum 39 183
• Lactobacillus fermentum 39 183
• Spray drying in the presence of prebiotics
• Scanning and transmission
• Pouzolzia zeylanica
• Optimize additional carrier
• Possess antioxidant
• The Journal of Agriculture and Development
• Tạp chí Nông nghiệp và Phát triển
• Spray drying microencapsulation
• β carotene
• Polysaccharide from yeast cell walls
• Microencapsulation yield (MEY)
• Microencapsulation efficiency (MEE)
• Red fleshed dragon fruit
• Hylocereus polyrhizus
• Spray drying conditions
• Maltodextrin concentration
• The physicochemical properties
• Spray dried papaya leaf powders
• Papaya leaf juice
• Total flavonoid content
• Physico chemical and organoleptic
• Spray dried ripe banana powder produced
• Packaging materials
• Skim milk powder
• Crumble feed
• Spray dried probiotics
• Crumble feed during storage
• Spray dried fermented milk products
• Fermented milk products
• Dried fermented dairy products
• Method causes minimal structural
• Bitter gourd powder
• Maltodextrin concentrations
• Feed flow rate
• Storage period
• kỹ thuật sấy phun
• sản xuất bột chanh dây
• quy trình sản xuất
• phương pháp nghiên cứu
• hệ thống sấy phun
• Granulation
• Engineering Perspective
• Drug Substance
• Roller Compaction Technology
• Granulation Technique
• Pharmaceutical Applications
• Excipient Characterization
• Blood level
• Rat paw oedema
• Thermal analysis
• Anti inflammatory activity
• Beverage powder
• Functional milk beverage powder
• Specific functionality
• Highly utilized techniques to increase
• Olive oil
• Wall materials
• Inlet air temperatures
• Microencapsulated of olive oil powder
• Carrot flavoured milk
• Gross energy
• Nutritional parameters
• Ready toreconstitute milk beverage
• Carbohydrate polymers
• Antioxidant activity
• Instrumental color
• Natural colorant
• Shelf life stability