tailieunhanh - Allogeneic hematopoietic stem cell transplantation for non-malignant hematological disorders

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) from a geno-identical matched sibling (MSD) is one of the most successful therapies in patients with non-malignant hematological disorders. This study included 273 patients with severe aplastic anemia (SAA), 152 patients with B-Thalassemia major (BTM), 31 patients with Fanconi’s anemia (FA), 20 patients with congenital immunodeficiency diseases (ID), and 13 patients with inherited metabolic disorders (IMD) allografted from a MSD. In SAA, the 8-year overall survival (OS) of the whole group patients was 74%. OS was significantly better in patients conditioned with fludarabine and cyclophosphamide (Flu/Cy) than in those who received cyclophosphamide and antithymocyte globulin (Cy/ATG) (p = ). Acute graft-versus-host disease (aGVHD) grade II–IV occurred in 15% while chronic GVHD (cGVHD) occurred in 28%. In BTM, the 12-year disease-free survival (DFS) of the whole group of BTM patients was . DFS was 74% for peripheral blood stem cell (PBSC) group compared to 64% in the BM stem cell group. The incidence of graft rejection was significantly lower in patients who received PBSC than in those who received BM (9% vs 25%) (p = ). AGVHD grade II–IV and cGVHD occurred in 15% and 12% of the whole group of BTM patients respectively. In FA, the 5-year OS was . Graft rejection occurred in 10% of patients. Grade II–IV aGVHD occurred in 16% while cGVHD occurred in 4%. In ID, the 5-year OS was 62%. Graft rejection occurred in two (10%) patients. | Allogeneic hematopoietic stem cell transplantation for non-malignant hematological disorders

• Y khoa - Dược
• Hematopoietic stem cell transplantation
• B thalassemia major
• Fanconi’s anemia
• Immunodeficiency diseases
• Inherited metabolic disorders
• BMC Cancer
• Cumulative incidence rates
• Transplantation related mortality
• Risk factor
• Acute leukemia
• Pre HSCT factors
• Graft versus host disease
• Post traumatic stress disorder
• Hospital Anxiety and Depression Scale
• Acute lymphoblastic leukemia
• Tyrosine kinase inhibitor
• Chronic myeloid leukemia
• Kinase inhibitors
• BMC Pediatrics
• Pediatric intensive care unit
• Possible predictive factors
• Pediatric critical illness score
• Peptides regulating gastrointestinal tract functions
• Gastrointestinal tract complications
• Acute graft versus
• Donor leukemia
• Whole exome sequencing
• Veno occlusive disease
• Cytokine serum
• Interleukin 8
• Acute myeloid leukemia
• Allogeneic hematopoietic stem cell transplantation
• Wilms’ tumor gene 1
• Prognostic role
• BMC Pulmonary Medicine
• Late onset noninfectious pulmonary complications
• Pleuroparenchymal fibroelastosis
• Idiopathic pneumonia syndrome
• Hematopoietic stem cell mobilization
• Peripheral blood stem cell transplantation
• Bone marrow
• Non Hodgkin’s lymphoma
• Area under the concentration time curve
• Meta analysis
• Childhood acute myeloid leukemia
• Allogeneic hematopoietic stem cell transplantation
• Pediatric acute myeloid leukemia
• Overall survival
• Intestinal mucositis
• Diamine oxidase
• Circulating citrulline
• High dose chemotherapy
• Autologous hematopoietic stem cell rescue
• High risk neuroblastoma
• Journal of clinical Medicine
• CT scan whole body
• Stem cell transplantation
• Large granular lymphocyte leukemia
• Graft versus lymphoma effect
• Terminal deoxynucleotidyl transferase
• HLA matched
• Pancreatic cancer
• Minimal residual disease
• Adjuvant chemotherapy
• Liver graft versus host disease
• Percutaneous liver biopsy
• Pediatric patients
• Child emotional distress
• Severe aplastic anemia
• Conditioning regimen
• Iron overload
• Matched sibling donor
• Peripheral blood stem cells
• Insufficient graft
• Autologous stem cell transplantation
• Multiple myeloma
• Umbilical cord
• Mesenchymal stem cells
• Wharton’s jelly
• immunogenetics
• neuron replacement therapy
• cover hematopoietic
• stem cells
• Cell Research
• Gene Therapy
• Extramedullary relapse
• Case report
• Acute T lymphoblastic leukemia
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