tailieunhanh - The role of reactive oxygen species in the antimicrobial activity of pyochelin

The increase in prevalence of antimicrobial-resistant bacteria (ARB) is currently a serious threat, thus there is a need for new antimicrobial compounds to combat infections caused by these ARB. An antimicrobial-producing bacterium, Burkholderia paludis was recently isolated and was able to produce a type of siderophore with antimicrobial properties, later identified as pyochelin. The chelating ability of pyochelin has been well-characterized but not for its antimicrobial characteristics. It was found that pyochelin had MIC values (MBC values) of mg/mL ( mg/mL) and mg/mL ( mg/mL) against three Enterococcus strains and four Staphylococcus strains. Pyochelin was able to inhibit E. faecalis ATCC 700802 (a vancomycin-resistant strain) in a time and dose dependent manner via killing kinetics assay. It was demonstrated that pyochelin enhanced the production of intracellular reactive oxygen species (ROS) over time, which subsequently caused a significant increase in malondialdehyde (MDA) production (a marker for lipid peroxidation) and ultimately led to cell death by disrupting the integrity of the bacterial membrane (validated via BacLight assay). This study has revealed the mechanism of action of pyochelin as an antimicrobial agent for the first time and has shown that pyochelin might be able to combat infections caused by E. faecalis in the future. | The role of reactive oxygen species in the antimicrobial activity of pyochelin

• Sinh học
• Antimicrobial compound
• Burkholderia paludis
• Enterococcus faecalis
• The role of reactive oxygen species
• Antimicrobial activity
• Production of an antibacterial compound
• Purification and characterization of an antibacterial compound
• Streptomyces griseus TBG19NRA1
• Antimicrobial activities
• Streptomyces griseus
• BMC Chemistry
• Single crystal
• Moderate antimicrobial activity
• Antioxidant manufacturing
• Cosmetics oxidation
• Lactococcus lactis subsp
• Lactococcin BZ
• 16S rDNA gene sequence homology
• Brain heart infusion
• BMC Biotechnology
• Phenolic acid
• Alternative antibiotic
• Flax seedcake
• Sub aerial cyanobacteria
• Bioactive molecules
• Antimicrobial agents
• Production and extraction
• Pharmaceutical applications
• Antimicrobial activity of ZITRITIDE
• Organic antimicrobial fogging solution
• Special reference
• Infection prevention
• Hospital environments
• Other clean room facilities
• Journal of Chemistry
• The Chemistry and Antimicrobial Activity of Psychotria reevesii Wall
• The Chemistry and Antimicrobial Activity
• Psychotria reevesii Wall
• The polar fractions against Staphylococcus aureus
• Pleurotus florida
• Silver nanoparticles
• Their antimicrobial activity
• Silver nanoparticles from pleurotus florida
• Oral pathogens
• Inhibition zone
• In vitro antimicrobial activity
• Commercial toothpastes
• Agar well diffusion method
• Salvia aegyptiaca
• Salvia aegyptiaca L
• Antimicrobial activity of various extracts
• Evaluation of antioxidant
• Syzygium cumin leaves
• Antimicrobial activity of Syzygium cumin leaves
• Ethyl acetate extracts
• Marine sediments
• 18S rRNA gene sequences
• Screening antimicrobial activity
• Identification of fungi
• Alternaria brassicae
• Aspergillus niger
• Pencillium notatum
• Underutilized fruits
• Antimicrobial activity of underutilized fruits
• Evaluation of antimicrobial activity
• Silver nanoparticles against pathogens
• Rhizome rot of ginger
• Chemical management in the future
• Thyme to antimicrobial activity
• Oregano essential oils
• Enzymatic antioxidative system
• Origanum vulgare L
• Antifungal activity
• Structure activity relationship
• Inhibition mechanism prediction
• Pentafluorophenylammonium triflate
• Coumarin 3 carboxylic acid
• Chromeno[2 3 d]pyrimidinones
• 4H pyran 5 ethylcarboxylate
• Antimicrobial activity of Vitamin B complex
• Klebsiella pneumoniae
• Klebsiella species isolated
• Water soluble vitamin B complex
• Biotechnology and food sciences
• Virulence factors
• Antibiotic resistance
• Antimicrobial activity of enterococcus spp isolated
• Acacia arabica
• Pathogenic organisms
• Control drug
• Antimicrobial activity of leaves
• Natural compounds from sponge
• Antimicrobial activity of natural compounds
• Derived fungus aspergillus flocculosus
• Marine derived fungi
• Protein hydrolysate prepared
• Tilapia fish waste
• Enzymatic treatment
• Antimicrobial properties in vitro
• Antimicrobial properties
• Phyo chemical analysis
• Plant resources having antimicrobial properties obtained
• Phytochemical analysis of plant resources
• Sonchus erzincanicus
• Antioxidant activity
• Minimal inhibition concentration
• Butylated hydroxytoluene
• Free radical
• Glutathione S transferase
• Hydroxyl radical
• Lipid peroxidation
• Desmostachya bipinnata stapf
• Root extracts of desmostachya bipinnata stapf
• Phytochemical analysis
• BMC Veterinary Research
• Antimicrobial peptide PMAP 37
• Antibacterial activity
• Therapeutic efficacy
• Antibacterial spectrum
• Anti biofilm activity
• Rhizophora stylosa
• Endophytic bacteria
• Mangrove plant Rhizophora stylosa
• Essential oils
• Oral diseases
• Anticariogenic activity
• Medicinally important essential oils
• Antimicrobial activity of medicinally
• In vitro anticariogenic activities