tailieunhanh - DJ-1 in ocular diseases: A review

Protein deglycase DJ-1 (Parkinson disease protein 7) is a 20 kDa protein encoded by PARK7 gene. It is also known as a redox-sensitive chaperone and sensor that protect cells against oxidative stress-induced cell death in many human diseases. Though increasing evidence implicates that DJ-1 may also participate in ocular diseases, the overview of DJ-1 in ocular diseases remains elusive. | Int. J. Med. Sci. 2018 Vol. 15 430 IVYSPRING ĩvt ơ-rnrt irmrtí clrni t n lí ei-fCMo Tir lT Qriữvtrơc INTERNATIONAL PUBLISHER international journal Oj jVLeaicaiSciences 2018 15 5 430-435. doi Review DJ-1 in Ocular Diseases A Review Cong Liu Xiufen Liu Jing Qi Om Prakash Pant Cheng-wei Lu and Jilong Hao Department of Ophthalmology The First Hospital of Jilin University Jilin China. Cong Liu and Xiufen Liu contribute equally to this manuscript. Corresponding authors Cheng-wei Lu lcwchina800@ and Jilong Hao 289736582@ Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution CC BY-NC license https licenses by-nc . See http terms for full terms and conditions. Received Accepted Published Abstract Protein deglycase DJ-1 Parkinson disease protein 7 is a 20 kDa protein encoded by PARK7 gene. It is also known as a redox-sensitive chaperone and sensor that protect cells against oxidative stress-induced cell death in many human diseases. Though increasing evidence implicates that DJ-1 may also participate in ocular diseases the overview of DJ-1 in ocular diseases remains elusive. In this review we discuss the role as well as the underlying molecular mechanisms of DJ-1 in ocular diseases including Fuchs endothelial corneal dystrophy FECD age-related macular degeneration AMD cataracts and ocular neurodegenerative diseases highlighting that DJ-1 may serve as a very striking therapeutic target for ocular diseases. Key words DJ-1 ocular disease oxidative stress Introduction Protein deglycase DJ-1 is coded by the human PARK7 gene on chromosome 1 1 and also named as Parkinson disease protein 7 due to the fact that DJ-1 was first discovered in Parkinson s disease PD patients 2 . DJ-1 is a member of the DJ-1 Hsp31 PfpI superfamily 3 . With a size of 20 kDa 4 DJ-1 consists of 189 amino acids 9 .