tailieunhanh - In vitro assessment of pharmaceutical potential of ethosomes entrapped with terbinafine hydrochloride

The present study investigates the entrapment of terbinafine hydrochloride (TH) in ethosomal vesicles via unsonicated and sonication method. Carbopol 934P was incorporated in the best formulation, F6, obtained by sonication method. The formulated ethosomal gel obtained as such . F6* was exploited to achieve a zero order release profile of TH. The composition includes phospholipid, ethanol and propylene glycol. Drug entrapment efficiency (DEE), invitro and ex-vivo drug diffusion studies, FT-IR and stability studies of the prepared ethosomes were investigated. The size and shape of F6 ethosomes vesicles were characterized by SEM. Invitro drug release studies were performed using sigma dialysis membrane in phosphate buffer, pH for 12 h while drug content was determined by HPLC. DEE was ranked from ± to ± . Highest DEE was seen with F6 ethosomal formulation with a vesicle size of 248 ± nm. FT-IR studies confirmed that there was no chemical interaction between drug and excipients used in the formulation. Ex-vivo result suggested that drug diffusion observed after 12 h from F6* and marketed cream (MR) formulations was ± and ± , respectively. The results of similarity factor (f2 values) for MR and F6* ethosomal gel were and , respectively. It revealed that F6* showed dissimilar dissolution profiles. Transdermal flux value for F6* and MR was found to be ± lg/cm2 /h and ± lg/cm2 /h, respectively. This study disclosed that F6* resides at targeted site for a relatively longer period of time thereby signifying the improved patient compliance. | In vitro assessment of pharmaceutical potential of ethosomes entrapped with terbinafine hydrochloride

• Y khoa - Dược
• In vitro drug diffusion
• Terbinafine Hydrochloride
• Transdermal flux
• Ethosomes entrapped
• Vitro assessment
• Goat milk
• In vitro assessment
• Antibiotic resistance pattern
• Lactobacillus strains isolated
• In vitro
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• Assessment of genetic fidelity
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• Antagonistic activity
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• In vitro micropropagation
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• Medicinal plant
• Toxicological Methods
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• Efficacy Testing
• Assessment Alternatives
• effective alternatives
• Vitro Toxicology
• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
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• Leaf explants
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• In vitro cytotoxicity
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• Anti cancer activity
• MTT assay
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• Micro organisms
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• Bee collected pollen against enterovirus D68
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• Antiviral activity against EV D68
• Bee hive products