tailieunhanh - Impact of PIVKA-II in diagnosis of hepatocellular carcinoma

Liver cancer grows silently with mild or no symptoms until advanced. In the absence of an effective treatment for advanced stage of hepatic cancer hope lies in early detection, and screening for high-risk population. Among Egyptians viral hepatitis is the most common risk factor for hepatocellular carcinoma (HCC). The current work was designed to determine the level of prothrombin induced by vitamin K absence-II (PIVKA-II) in sera of patients suffering from HCC and hepatitis C virus (HCV) patients being the most common predisposing factor for HCC. Our ultimate goal is diagnosis of HCC at its early stage. The current study was carried out on 83 individuals within three groups; Normal control, HCV and HCC groups. Patients were subdivided into cirrhotic and non-cirrhotic. | Journal of Advanced Research 2013 4 539-546 Cairo University Journal of Advanced Research ORIGINAL ARTICLE Impact of PIVKA-II in diagnosis of hepatocellular carcinoma CrossMark Nadia I. Zakhary a Sherif M. Khodeer b Hanan E. Shafik c Camelia A. Abdel Malak b a Cancer Biology Department National Cancer Institute Cairo University Cairo Egypt b Chemistry Department Faculty of Science Mansoura University Mansoura Egypt c Medical Oncology Department National Cancer Institute Cairo University Cairo Egypt Received 29 February 2012 revised 22 October 2012 accepted 28 October 2012 Available online 11 January 2013 KEYWORDS PIVKA-II Hepatocelluler carcinoma Early diagnosis Abstract Liver cancer grows silently with mild or no symptoms until advanced. In the absence of an effective treatment for advanced stage of hepatic cancer hope lies in early detection and screening for high-risk population. Among Egyptians viral hepatitis is the most common risk factor for hepatocellular carcinoma HCC . The current work was designed to determine the level of prothrombin induced by vitamin K absence-II PIVKA-II in sera of patients suffering from HCC and hepatitis C virus HCV patients being the most common predisposing factor for HCC. Our ultimate goal is diagnosis of HCC at its early stage. The current study was carried out on 83 individuals within three groups Normal control HCV and HCC groups. Patients were subdivided into cirrhotic and non-cirrhotic. Complete clinicopathological examination was carried out for each individual to confirm diagnosis. Individuals sera were subjected to quantitative determination of alpha-fetoprotein AFP PIVKA-II and other parameters. PIVKA-II proved to be superior to AFP for early detection of HCC patients being highly sensitive and specific. Furthermore it has the ability to discriminate between different histopathological grades of HCC and It has a powerful diagnostic validity to evaluate the thrombosis of portal vein and to differentiate between early and

• Y khoa - Dược
• PIVKA II
• Hepatocelluler carcinoma
• Early diagnosis
• Impact of PIVKA II in diagnosis
• HCV and HCC groups