tailieunhanh - Hepatitis C virus and cardiovascular: A review

Chronic hepatitis C virus (HCV) infection is a systemic disease that leads to increased risks of cirrhosis and its complications, as well as extrahepatic disturbances, including immune-related disorders and metabolic alterations such as insulin resistance and steatosis. Recent accumulating evidence suggests that HCV infection can increase cardiovascular risk, and that viral eradication can improve cardiovascular outcomes in the clinical setting. These data are strengthened by evidence identifying potential mechanisms (in)directly linking HCV infection to vascular damage. However, the high prevalence of both HCV infection and cardiovascular alterations, as well as the presence of contrasting results not identifying any association between HCV infection and cardiovascular dysfunction, provides uncertainty about a direct association of HCV infection with cardiovascular risk. Further studies are needed to clarify definitively the role of HCV infection in cardiovascular alterations, as well as the impact of viral eradication on cardiovascular outcomes. These features are now more attractive, considering the availability of new, safe, and very effective interferon-free antiviral agents for the treatment of HCV infection. This review aims to discuss carefully available data on the relationship between HCV infection and cardiovascular risk. | Journal of Advanced Research 2017 8 161-168 Cairo University Journal of Advanced Research REVIEW Hepatitis C virus and cardiovascular A review CrossMark Salvatore Petta Sezione di Gastroenterologia Dipartimento Biomedico di Medicina Interna e Specialistica Piazza delle Cliniche 2 90127 Palermo Italy GRAPHICAL ABSTRACT HCV and Cardiovascular Disorders Salvatore Petta Section of Gastroenterology . University of Palermo Italy HCV Infection Carotid Coronary Atheroscleosis High Arterial Stiffness Peripheral Artery Disease Myocardial Injury Cardiovascular Events Cerebrovascular Events Ciovascular Mortality HCV Infection is a systemic disease associated with both hepatic and extrahepatic complications including increased cardiovascular risk by both direct and indirect mechanisms. Preliminary evidences suggest an improvement of cardiovascular outcomes in patients with virological eradication even if large prospective studies should well investigate this clinically relevant issue ARTICLE INFO ABSTRACT Article history Received 25 February 2016 Received in revised form 5 June 2016 Accepted 11 June 2016 Available online 18 June 2016 Keywords hCv Cardiovascular risk Chronic hepatitis C virus HCV infection is a systemic disease that leads to increased risks of cirrhosis and its complications as well as extrahepatic disturbances including immune-related disorders and metabolic alterations such as insulin resistance and steatosis. Recent accumulating evidence suggests that HCV infection can increase cardiovascular risk and that viral eradication can improve cardiovascular outcomes in the clinical setting. These data are strengthened by evidence identifying potential mechanisms in directly linking HCV infection to vascular damage. However the high prevalence of both HCV infection and cardiovascular alterations as well as the presence of contrasting results not identifying any association between HCV infection and cardiovascular dysfunction provides uncertainty about a .