tailieunhanh - Hepatic and Intestinal Schistosomiasis: Review

Schistosomiasis is an endemic disease in Egypt caused by the trematode Schistosoma which has different species. c the best known form of chronic disease with a wide range of clinical manifestations. The pathogenesis of schistosomiasis is related to the host cellular immune response. This leads to granuloma formation and neo angiogenesis with subsequent periportal fibrosis manifested as portal hypertension, splenomegaly and esophageal varices. Intestinal schistosomiasis is another well identified form of chronic schistosomal affection. Egg deposition and granuloma formation eventually leads to acute then chronic schistosomal colitis and is commonly associated with polyp formation. It frequently presents as abdominal pain, diarrhea, tenesmus and anal pain. Definite diagnosis of schistosomiasis disease depends on microscopy and egg identification. Marked progress regarding serologic diagnosis occurred with development of recent PCR techniques that can confirm schistosomal affection at any stage. Many antischistosomal drugs have been described for treatment, praziquantel being the most safe and efficient drug. Still ongoing studies try to develop effective vaccines with identification of many target antigens. Preventive programs are highly needed to control the disease morbidity and to break the cycle of transmission. | Hepatic and Intestinal Schistosomiasis: Review Journal of Advanced Research (2013) 4, 445–452 Cairo University Journal of Advanced Research REVIEW Hepatic and Intestinal Schistosomiasis: Review Tamer Elbaz, Gamal Esmat * Endemic Medicine Department, Faculty of Medicine, Cairo University, Egypt Received 26 July 2012; revised 5 December 2012; accepted 7 December 2012 Available online 11 January 2013 KEYWORDS Abstract Schistosomiasis is an endemic disease in Egypt caused by the trematode Schistosoma Hepatic schistosomiasis; which has different species. Hepatic schistosomiasis represents the best known form of chronic dis- Portal hypertension; ease with a wide range of clinical manifestations. The pathogenesis of schistosomiasis is related to Intestinal schistosomiasis; the host cellular immune response. This leads to granuloma formation and neo angiogenesis with Praziquantel subsequent periportal fibrosis manifested as portal hypertension, splenomegaly and esophageal var- ices. Intestinal schistosomiasis is another well identified form of chronic schistosomal affection. Egg deposition and granuloma formation eventually leads to acute then chronic schistosomal colitis and is commonly associated with polyp formation. It frequently presents as abdominal pain, diarrhea, tenesmus and anal pain. Definite diagnosis of schistosomiasis disease depends on microscopy and egg identification. Marked progress regarding serologic diagnosis occurred with development of recent PCR techniques that can confirm schistosomal affection at any stage. Many antischistosomal drugs have been described for treatment, praziquantel being the most safe and efficient drug. Still ongoing studies try to develop effective vaccines with identification of many target antigens. Preven- tive programs are highly needed to control the disease morbidity and to break the cycle of transmis- sion. ª 2012 Cairo University. Production and hosting .

• Y khoa - Dược
• Hepatic schistosomiasis
• Portal hypertension
• Intestinal schistosomiasis
• Host cellular immune response
• Chronic schistosomal affection
• Urinary Schistosomiasis
• Hepatosplenic schistosomiasis
• Bladder cancer
• Hepatitis C
• Hepatic co morbidity
• Effect of artemether
• Cytokine profile
• Egg induced pathology
• Murine schistosomiasis mansoni
• Hepatic granulomatous lesions