tailieunhanh - Hematologic malignancies during pregnancy: A review

Malignancy is the second most common cause of mortality in the reproductive period and it complicates up to one out of every 1000 pregnancies. When cancer is diagnosed during pregnancy, the management approach must take into consideration both the mother and her fetus. Hematologic cancers diagnosed in pregnancy are not common, resulting in paucity of randomized controlled trials. Diagnosis of such malignancies may be missed or delayed, as their symptoms are similar to those encountered during normal pregnancy. Also, many imaging studies may be hazardous during pregnancy. Management of these malignancies during pregnancy induces many treatment-related risks for mother and baby and should consider patient’s preferences for pregnancy continuation. In this article, hematologic malignancies diagnosed in pregnant patients including acute leukemias, chronic myeloid leukemia, lymphomas, multiple myeloma and myeloproliferative neoplasms, will be reviewed, including diagnostic and management strategies and their impact on the pregnant patient and the developing fetus. | Journal of Advanced Research 2016 7 589-596 Cairo University Journal of Advanced Research REVIEW Hematologic malignancies during pregnancy A review CrossMark Hossam K. Mahmoud a Mohamed A. Samraa Gamal M. Fathyb a Department of Medical Oncology National Cancer Institute Cairo University Egypt b Department of Hematology and BMT Nasser Institute for Research and Treatment Ministry of Health Egypt GRAPHICAL ABSTRACT ARTICLE INFO ABSTRACT Article history Received 20 September 2015 Received in revised form 3 February 2016 Accepted 3 February 2016 Available online 8 February 2016 Malignancy is the second most common cause of mortality in the reproductive period and it complicates up to one out of every 1000 pregnancies. When cancer is diagnosed during pregnancy the management approach must take into consideration both the mother and her fetus. Hematologic cancers diagnosed in pregnancy are not common resulting in paucity of randomized controlled trials. Diagnosis of such malignancies may be missed or delayed as their symptoms are similar to those encountered during normal pregnancy. Also many imaging studies may be hazardous during pregnancy. Management of these malignancies during pregnancy Corresponding author. Tel. 20 1001720769 fax 20 2 36447200. E-mail address abdelmooti@ . Samra . Peer review under responsibility of Cairo University. Production and hosting by Elsevier http 2090-1232 2016 Production and hosting by Elsevier . on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license http licenses by-nc-nd . 590 . Mahmoud et al. Keywords Hematologic malignancies Pregnancy Acute leukemias Chronic myeloid leukemia Lymphomas induces many treatment-related risks for mother and baby and should consider patient s preferences for pregnancy continuation. In this article hematologic malignancies diagnosed in pregnant patients including acute leukemias chronic .