tailieunhanh - Association between single nucleotide polymorphism in miR-499, miR-196a2, miR-146a and miR-149 and prostate cancer risk in a sample of Iranian population

MicroRNAs (miRNAs) play an important role in regulating gene expression at the posttranscriptional level and are involved in numerous physiological processes. Accumulating evidence suggests that single-nucleotide polymorphisms (SNPs) in human miRNA genes may affect miRNA biogenesis pathway and influence the susceptibility to several diseases such as cancer. The present study aimed to evaluate the impact of miR-499 rs3746444, miR-196a2 rs11614913, miR-149 rs2292832, and miR-146a rs2910164 polymorphisms on prostate cancer (PCa) risk in a sample of Iranian population. This case-control study was done on 169 patients with pathologically confirmed PCa and 182 benign prostatic hyperplasia (BPH). The genotyping assays were done using T-ARMS-PCR or PCR-RFLP methods. The findings indicated that CC genotype of miR-499 rs3746444 polymorphism increased the risk of PCa (OR = , 95% CI = –, P = ) compared to TT genotype. No statistically significant association was found between miR-196a2 rs11614913, miR-149 rs2292832, and miR-146a rs2910164 polymorphisms and PCa risk. In summary, the findings indicated that miR-499 rs3746444 polymorphism increased the risk of PCa in an Iranian population. Further studies with larger sample sizes and different ethnicities are necessary to verify the findings of the present study. | Association between single nucleotide polymorphism in miR-499, miR-196a2, miR-146a and miR-149 and prostate cancer risk in a sample of Iranian population

• Y khoa - Dược
• Prostate cancer
• Single nucleotide polymorphism
• Prostate cancer risk
• Iranian population
• Regulating gene expression
• Radiation therapy
• Clinical management
• Metastatic prostate cancer
• Localized prostate cancer
• BMC Cancer
• Initial prostate biopsy
• Diagnose prostate cancer
• Probability density functions
• Adenocarcinoma of prostate
• Androgen independent prostatic cancer
• Docetaxel resistance
• Anti neoplastic agent resistance
• Doctor of Medicine summary
• Application of 12 core prostate biopsy
• Transrectal ultrasound guidance
• Diagnosis of prostate cancer
• Castration resistant prostate cancer
• Androgen concentrations
• Measure testosterone
• Chromosomal instability
• Prostate needle biopsies
• Amino acids
• Prostate cancer biomarkers
• Prostate specific antigen
• Diagnostic biomarkers
• Biological fluids
• Metastatic castrate resistant
• Prostate specific antigen while
• Health implications
• GnRH antagonist
• GnRH agonist
• Neoadjuvant androgen deprivation therapy
• Quality of life
• Non invasive biomarkers
• Benign prostate hyperplasia
• Diagnostic dilemma
• Prostate specific antigen doubling time
• Personalized peptide vaccine
• Surrogate marker
• Overall survival
• Recombinant antibody
• Human dendritic cells
• The medical doctoral thesis
• Histopathological fearures immunohistochemistry
• Methylation of rassf1a gene in prostate cancer
• Rassf1a gene in prostate cancer
• Istopathological features in prostate carcinoma
• Genome Biology
• DNA methylation
• Slow growing prostate cancer
• Prostate specifc antigen decline rate per week
• Degree of prostatic collapse
• Tissue signal rate of prostate
• Prostatitis disease
• Endocrine therapy
• Hormone treatment
• Cancer patients treated
• Cancer surveillance series
• Cell migration
• Cell invasion
• Above mentioned cytokines
• High cancer related deaths
• Prostate intraepithelial neoplasia
• PSGR protein
• Cancer cell growth
• Regulatory T cell
• Platinum based chemotherapy
• Multiple cancer cell lines
• Anti prostate cancer
• Frequently diagnosed cancer
• PC3 cell migration
• Human prostate cancer
• Breast and prostate cancer
• Expression of NRIF3
• Breast cancer
• Transcriptional repressor
• Targeted imaging
• Orthotopic prostate cancer
• Clinical transformable
• Photoacoustic imaging system
• Meta analysis
• Precise mechanism
• Tumor cells
• Recurrent prostate cancer
• Salvage radiation therapy
• High risk prostate cancer
• Primary hypothesis
• Protein tyrosine phosphatase non receptor 12
• Quantitative Gleason grade