tailieunhanh - Circular RNAs: Novel promising biomarkers in ocular diseases

Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs produced by back-splicing. They are found to be expressed in eukaryotic cells and play certain roles in various cellular functions, including fibrosis, cell proliferation, differentiation, apoptosis and angiogenesis. | Int. J. Med. Sci. 2019 Vol. 16 513 IVYSPRING ĩvt ơ-rnrt irmrtí clrni t n lí ei-fCMo Tir lT Qriữvtrơc INTERNATIONAL PUBLISHER international journal Oj jVLeaicaiSciences 2019 16 4 513-518. doi Review Circular RNAs Novel Promising Biomarkers in Ocular Diseases Nan Guo1 Xiu-fen Liu1 Om Prakash Pant1 Dan-Dan Zhou2 Ji-long Hao1 Cheng-wei Lu1 1. Department of Ophthalmology 2. Department of Radiology The First Hospital of Jilin University No. 71 of xinmin St. Changchun Jilin Province 130021 China. Nan Guo Xiu-fen Liu Om Prakash Pant Dan-Dan Zhou are co-first authors. E Corresponding authors Cheng-wei Lu . . Department of Ophthalmology the First Hospital of Jilin University No. 71 of xinmin St. Changchun Jilin Province 130021 China. Email address lcwchina800@ Telephone No 8618684317115 and Ji-long Hao . . Department of Ophthalmology the First Hospital of Jilin University No. 71 of xinmin St. Changchun Jilin Province 130021 China. Email address 289736582@ Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution CC BY-NC license https licenses by-nc . See http terms for full terms and conditions. Received Accepted Published Abstract Circular RNAs circRNAs are a novel class of endogenous non-coding RNAs produced by back-splicing. They are found to be expressed in eukaryotic cells and play certain roles in various cellular functions including fibrosis cell proliferation differentiation apoptosis and angiogenesis. Dysregulated circRNAs are found in several human disorders including malignancy vascular inflammatory as well as nervous diseases. Although increasing evidence suggests that circRNAs may also contribute in different ocular diseases the outline of circRNAs in ocular diseases remains obscure. In this review we consider the current state of knowledge regarding the potential role and .

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