tailieunhanh - Butenafine and analogues: An expeditious synthesis and cytotoxicity and antifungal activities

The incidence of fungal infections is considered a serious public health problem worldwide. The limited number of antimycotic drugs available to treat human and animal mycosis, the undesirable side effects and toxicities of the currently available drugs, and the emergence of fungal resistance emphasizes the urgent need for more effective antimycotic medicines. In this paper, we describe a rapid, simple, and efficient synthetic route for preparation of the antifungal agent butenafine on a multigram scale. This novel synthetic route also facilitated the preparation of 17 butenafine analogues using Schiff bases as precursors in three steps or less. All the synthesized compounds were evaluated against the yeast, Cryptococcus neoformans/C. gattii species complexes and the filamentous fungi Trichophyton rubrum and Microsporum gypseum. Amine 4bd, a demethylated analogue of butenafine, and its corresponding hydrochloride salt showed low toxicity in vitro and in vivo while maintaining inhibitory activity against filamentous fungi. | Butenafine and analogues: An expeditious synthesis and cytotoxicity and antifungal activities

• Sinh học
• Antifungal activity
• Microwave assisted synthesis
• Expeditious synthesis
• Cytotoxicity and antifungal activities
• Antifungal activities
• Sol gel
• Sol gel technique
• Characteristics and antifungal activity
• CuO ZnO nanocomposites synthesised
• Essential oil
• Antifungal activity against
• Composition of essential oils
• Essential oils
• Colletorichum falcatum
• Lantana camara
• Wild sage (Lantana camara)
• Antifungal activity of wild sage
• Aspergillus species
• Antifungal action
• Curcumin against Aspergillus flavus
• Evaluation of antifungal activity
• Poultry feed
• Serratia marcescens
• Enzyme activity
• Cell immobilization
• Phytopathogenic fungi
• BMC Chemistry
• Structure–activity relationship
• Hydrazone moiety
• Lichen extracts
• Antifungal agents against dermatophytes
• Potential role
• Selected lichens collected
• Cultural conditions
• Production of antifungal bioactive metabolites
• Streptomyces spp
• Cultural conditions for production
• Termite mound soil
• Fungal pathogens
• Antibacterial activity
• Bacterial strains
• Cow urine
• Seed borne microflora
• Evaluation of antibacterial
• Antifungal activity of cow urine against
• Ibuprofen antifungal activity
• Both planktonic
• Biofilm forms of fluconazole resistant
• Action evaluated
• Flow cytometry
• Biofilm forms
• Aspergillus fumigatus
• Candida albicans
• Pathogenic fungi Candida albicans
• Essential oils from some plants
• Isolation of chitinase producing bacteria
• Selection of chitinase producing bacteria
• Antifungal activity against fusarium oxysporum from lilium rhizosphere soil
• Lilium rhizosphere soil
• Chitinase producing bacteria
• Journal of Biology
• Medicago truncatula
• Pathogenesis related proteins
• Protein expression
• Thaumatin like protein
• Bacillus licheniformis
• Fusarium oxysporum
• Fusarium equiseti
• Culture condition
• Minimum inhibitory concentrations
• Agar well diffusion
• Shizophyllum commune
• Muntingia calabura
• Fungal pathogen
• Muntingia calabura root
• Mycelial growth
• Gloriosa superba
• Different plant parts
• Plant parts of glory lily
• Studies on antifungal activity
• Journal of Chemistry
• Ooxime ether
• Keto ester
• DNA binding
• Turkish Journal of Chemistry
• Tạp chí Hóa học
• Cation sensors
• Binding attitude
• Molecular docking
• MLCT band
• Complimented antifungal activity
• Antimicrobial activity
• Structure activity relationship
• Inhibition mechanism prediction
• Clerodendrum inerme
• Clerodendrum phlomidis
• Human pathogenic fungi
• Ethyl acetate extract of C
• inerme
• Red rot tolerant sugarcane
• Antifungal gene
• Colletotrichum falcatum Went
• Sugarcane transformation
• Chitinase gene
• Chitinase activity
• Transgene mRNA expression
• Medicinal plants
• Sequential extraction
• Botanicals against plant pathogens