tailieunhanh - Mini review: Micro RNA in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a highly invasive and malignant tumor of the nasopharynx, the uppermost region of the pharynx, gravitating toward Southeast Asia, especially Vietnam. The etiology of NPC is suggested to be involved to several genetic susceptibility and environmental factors. miRNAs (microRNA), the short non-coding RNA molecular, have been reported that played important roles, as oncogene and/or tumor suppressor gene, in progression and development of NPC. | Journal of Science Ho Chi Minh City Open University - VOL. 1 17 2016 - April 2016 35 MINI REVIEW MICRO RNA IN NASOPHARYNGEAL CARCINOMA Lao Duc Thuan1 Nguyen Hoang Anh Tuan2 Nguyen Van Truong3 Nguyen Huu Dung4 Le Huyen Ai Thuy5 1 5 Ho Chi Minh City Open University Vietnam. 2University of Science Vietnam National University Ho Chi Minh City. 3Ho Chi Minh City International University Vietnam National University HCMC. 4Cho Ray Hospital Vietnam. Email Received 04 03 2016 Revised 23 03 2016 Accepted 29 03 2016 ABSTRACT Nasopharyngeal carcinoma NPC is a highly invasive and malignant tumor of the nasopharynx the uppermost region of the pharynx gravitating toward Southeast Asia especially Vietnam. The etiology of NPC is suggested to be involved to several genetic susceptibility and environmental factors. miRNAs microRNA the short non-coding RNA molecular have been reported that played important roles as oncogene and or tumor suppressor gene in progression and development of NPC. In this review we summarized the role of miRNAs in NPC and their potential use as biomarkers for early prognosis and diagnosis of NPC as well as therapeutic agent of NPC in future. Keywords miRNA nasopharyngeal carcinoma biomarkers therapeutic agents. 1. Introduction miRNAs Mirco RNA originally discovered in Caenorhabditis elegans are the short non-coding RNA molecular within about 20-23 nucleotides nts in length that involved in post-transcriptional gene regulation Chuang Jones 2007 Macfarlane Murphy 2010 Sata et al. 2011 Jeff Fei-Fei 2014 . miRNAs have been shown to provide insight into both biological and clinical behavior of numerous human cancers including nasopharyngeal carcinoma NPC . miRNAs have been found to play important roles in cellular processing including signal pathways related to cancer progression functioning as tumor suppressor genes and or oncogenes Esquela-Kerscher Slack 2006 Sata et al. 2011 Jeff Fei-Fei 2014 . miRNAs regulate gene expression by binding to .

• Nông nghiệp
• Nasopharyngeal carcinoma
• Therapeutic agents
• Micro RNA
• Malignant tumor of the nasopharynx
• Several genetic susceptibility
• Non coding RNA molecular
• Silico single polymorphism
• Polymorphism analysis of RPMS1
• A73 gene in nasopharyngeal carcinoma
• NPC treatment
• BMC Cancer
• Cumulative dose
• High cumulative doses
• Non metastatic nasopharyngeal carcinoma
• Cisplatin related toxicities
• Epstein Barr virus–associated malignancy
• Human nasopharyngeal carcinoma
• Radioresistant NPC cell line
• E cad gene
• DNA hypermethylation
• Tumor suppressor genes
• EBNA 1
• Vietnamese population
• Epstein Barr virus nuclear antigen 1
• Gene prevalence
• Cell free Epstein Barr virus DNA
• Quantitative PCR
• Ultrasensitive PCR assay
• Early detection of nasopharyngeal carcinoma
• MiRNA 214; Nasopharyngeal carcinoma
• Applied bioinformatics tools
• Microrna 214 expression
• Potential targets genes
• Nasopharyngeal cancer
• Pathological characteristics
• Hue Central Hospital
• Keratinizing squamous cell carcinoma
• Nanoparticle albumin bound paclitaxel
• Plus cisplatin
• Metastatic nasopharyngeal carcinoma
• Milk consumption
• Ecological study
• Decreasing trends of nasopharyngeal carcinoma
• Nasopharyngeal neoplasms
• Intensity modulated radiotherapy
• Magnetic resonance imaging
• Disease related death
• Distant metastasis
• Chemoradiotherapy treatment
• MRN complex
• DNA double strand breaks
• Facilitating radioresistance
• Quantitative phosphoproteomics
• Nasopharyngeal epithelium
• Underlying mechanism
• Staging system
• Intensity modulated radiation therapy
• Cigarette smoking
• Epstein Barr virus
• Nasopharyngeal EBV load
• Nasopharyngeal EBV reactivation
• Undifferentiated carcinoma
• Ung thư Nasopharyngeal carcinoma
• Đại cương Ung thư vòm
• Triệu chứng lâm sàng ung thư vòm
• Bệnh học nội khoa
• Sinh lý bệnh
• Ung thư vòm họng
• Nasopharyngeal carcinoma patients
• Cell free Epstein Barr virus
• Plasma cell free DNA
• Sensitive realtime PCR
• Cancer tumor node metastasis
• Cell cycle
• Cyclin dependent kinase inhibitor 3
• Local recurrence free survival
• Distant metastasis free survival
• Aqueous extract of Ajuga bracteosa
• Mitosis delay
• Primary treatment methods
• Against NPC remain unclear
• Ajuga bracteosa
• Methylation of Ecadherin gene
• Ecadherin gene
• Increased risk
• DNA methylation
• Distinct geographical distribution
• Gathered public attention
• HNE1 cells
• Cell metastasis
• Induction chemotherapy
• Concurrent chemoradiotherapy
• Randomized controlled clinical trials