tailieunhanh - Synthesis and evaluate the degradation of isoamyl nitrite

Isoamyl nitrite (IAN) is one of antidotes for cyanide poisoning. IAN can be synthesized by many different ways. IAN is degraded easily in normal conditions, requiring the evaluation of degradation after synthesis. Physical - chemical properties as well as the results of synthesis and evaluation of degradation are presented in this paper. | Chemistry Environment SYNTHESIS AND EVALUATE THE DEGRADATION OF ISOAMYL NITRITE Vu Ngoc Toan Nguyen Minh Tri Le Hong Minh Abstract Isoamyl nitrite IAN is one of antidotes for cyanide poisoning. IAN can be synthesized by many different ways. IAN is degraded easily in normal conditions requiring the evaluation of degradation after synthesis. Physical - chemical properties as well as the results of synthesis and evaluation of degradation are presented in this paper. The results showed that the product stored in vacuum ampoule with stabilizer K2CO3 2 wt increased the shelf life more than 12 months yield 80-85 . Keywords Isoamyl nitrite Antidote Cyanide. 1. INTRODUCTION Inhaling isoamyl nitrite IAN has been first aid measure for cyanide-poisoned victims in many years 8 9 . However the effectiveness of IAN is still controversial nowday. Some studies said that IAN could not produce more than 6 methemoglobin while the necessary quantity antidote is 15 for LD50 dose of cyanide 9 . Other reports said that IAN is only support solution for treatment cyanide victims. Now the protective effect of IAN is attributed to its vasodilatory effect that can reverse the early cyanide induced vasoconstriction 2 9 . Artificial ventilation with IAN broken into ampul bags has been reported as a life saving therapy in cyanide poisoned dogs prior to induction of significant level of methemoglobinemia 6 . In addition IAN is used for treating heart diseases and angina. Especially IAN is also used as stimulant drug combining with other drugs to create a feeling like using cocaine or methylenedioxyl methamphetamine 5 . Therefore IAN was only synthesized in small amounts for medical purposes. IAN can be easily synthesized in laboratory but it quickly decomposes into other products under normal conditions. In this paper we present method for synthesis determine structure of product and as the level of degradation when using stabilizer. 2. EXPERIMENTAL . Chemical equipment and method . .