tailieunhanh - TCD4 cell disorder in patients with severe infections

The main studied aspects were risk factors in order to initial investigate relationship between severe infections and TCD4 cell depletion. Subjects and methods: Cross-sectional studies. 79 patients with severe infection and negative HIV test who were admitted at the Intensive Care Unit and Emergency Department of National Hospital for Tropical Diseases (Vietnam) from April 2017 to March 2018 were evolved in our study. Results: The mean age at diagnosis was ± years, range: 24 to 90. 60 patients (76%) were males, 19 (24%) were females. This group had many different occupations, including farmer, worker, office staff. Outside the 28 patients with a history of healthy, the risk factors were documented in 15 () with habit of smoking and/or drinking, 38 patients () had 1 to 3 chronic diseases, including 10 patients with immunodeficiency caused by pathological malignancy (7 patients), autoimmune disease (4 patients) and inborn pituitary failure (1 patient). | JOURNAL OF MILITARY PHARMACO-M DICIN N 2-2019 TCD4 CELL DISORDER IN PATIENTS WITH SEVERE INFECTIONS Bui Vu Huy1 Tran Van Kien1 Ta Thi Dieu Ngan1 SUMMARY Objectives The main studied aspects were risk factors in order to initial investigate relationship between severe infections and TCD4 cell depletion. Subjects and methods Cross-sectional studies. 79 patients with severe infection and negative HIV test who were admitted at the Intensive Care Unit and Emergency Department of National Hospital for Tropical Diseases Vietnam from April 2017 to March 2018 were evolved in our study. Results The mean age at diagnosis was years range 24 to 90. 60 patients 76 were males 19 24 were females. This group had many different occupations including farmer worker office staff. Outside the 28 patients with a history of healthy the risk factors were documented in 15 with habit of smoking and or drinking 38 patients had 1 to 3 chronic diseases including 10 patients with immunodeficiency caused by pathological malignancy 7 patients autoimmune disease 4 patients and inborn pituitary failure 1 patient . None of them had a family history of any similar disease. All patients had negative HIV test. Clinical diagnosis of 79 patients sepsis disease 43 patients respiratory tract infection 24 patients and central nervous system infection 12 patients . The mean value of CD4 cells was 338 . All patients had an infection status with elevated levels of CRP procalcitonine and white blood cell counts although only of patients were identified pathogens. The evidence showed alcoholism condition and smoking were associated with the decline of CD4 cells but the underlying disease and infectious diseases didn t related to this situation. Conclusion Severe infections may associate with decrease in CD4 cells on individuals with or without underlying disease. It should be interested to diagnosis and treat opportunistic infections as well as preventive treatment .

• Y khoa - Dược
• TCD4 cell disorder
• Patients with severe infections
• Autoimmune diseases
• Idiopathic CD4 lymphocytopenia
• Opportunistic infections