tailieunhanh - Summary of materials science doctoral thesis: Study on fabrication and effectiveness evaluation of multifunctional nanosystem (polymer-drug-Fe3O4-folate) on cancer cells

The objectives of the thesis: Manufacturing multifunctional nanoparticles including: Fe3O4 nanoparticles (magnetical properties) coated with biocompatible polymers, attaching drugs (Cur, Dox) and targeted folate factor (optical properties)) that are well dispersed in water, able to target the and evaluate the effect of the nanoparticles on cancer cell lines such as HT29; HeLa; HepG2 . and on experimental animals. | Summary of materials science doctoral thesis: Study on fabrication and effectiveness evaluation of multifunctional nanosystem (polymer-drug-Fe3O4-folate) on cancer cells MINISTRY OF EDUCATION VIETNAM ACADEMY AND TRAINING OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY .*** LE THI THU HUONG Study on fabrication and effectiveness evaluation of multifunctional nanosystem (polymer-drug-Fe3O4-folate) on cancer cells Major: Electronic materials Code: 9440123 SUMMARY OF MATERIALS SCIENCE DOCTORAL THESIS Hanoi – 2018 This thesis was finished at Institute of Mataerials Science and Graduate university of Science and Technology, Vietnam Academy of Science and Technology Supervisor 1: Dr. Ha Phuong Thu Supervisor 2: Prof. Dr. Nguyen Xuan Phuc Reviewer 1: Reviewer 2: Reviewer 3: . This thesis will be defended against Board of thesis defense at Graduate university of Science and Technology – Vietnam Academy of Science and Technology at , Date It can be found at: - Library of Graduate university of Science and Technology - Vietnam National Library INTRODUCTION 1. The urgency of the thesis Today, the development of science and technology has made great strides in biomedical science but human beings are still facing many diseases, most notably cancer. There are many cancer drugs available on the market. However, the biggest disadvantage of many cancer drugs is that they are less soluble in water or more readily excreted. Besides, the selectivity of these drugs is not high, and more or less affects healthy tissues and results in side effects including nausea, diarrhea, anemia or reduced immunity of the body. This is due to most treatments not only affect the tumor locally, but also affect a large part of the body's normal tissues and organs. To overcome the shortcomings of the method above, researchers have applied nanotechnology, using .