tailieunhanh - Diagnosis and clinical management in prostate cancer: Part 2

(BQ) Continued part 1, part 2 of the document Diagnosis and clinical management in prostate cancer has contents: Radiation therapy in the management of prostate cancer, novel therapies for localized prostate cancer, diagnosis and management of metastatic prostate cancer, end of life care in prostate cancer,. and other contents. Invite you to refer. | CHAPTER 9 Radiation Therapy in the Management of Prostate Cancer J. Conibear1 and . Hoskin2 1Mount Vernon Cancer Centre Middlesex UK 2University College London Mount Vernon Cancer Centre Northwood UK Introduction Radiation is one of the principal treatment modalities for prostate cancer 1 2 . Since the early twentieth century radiation has been used to treat all stages of the disease. In 1904 Armand and Leon Imbert were the first clinicians to report on the successful use of X-ray therapy to treat an advanced prostate cancer 3 . In 1908 both Minet and Desnos used radium-containing catheters to deliver an early form of brachytherapy and in 1923 Waters and Pierson used deep X-rays to treat a prostate cancer bony metastasis 4-7 . Over the past century radiation therapy for prostate cancer has undergone dramatic changes as a result of advances in radiobiology physics and computer technology. Now in the twenty-first century practitioners of prostate cancer radiation therapy can tailor their treatments to the stage and needs of the patient. External beam radiotherapy The first attempts to use X-rays to treat prostate cancer relied upon low-energy beams. Compared to modern megavoltage X-rays they lacked the comparative depth of penetrance and consequently led to high-radiation doses at the patient s skin surface. This meant early prostate cancer patients suffered significant acute skin toxicity and an increased risk of radiation-induced skin cancers. Due to these early drawbacks the use of low-energy beams to treat localized prostate cancer remained relatively low in the first half of the twentieth century. Prostate Cancer Diagnosis and Clinical Management First Edition. Edited by Ashutosh K. Tewari Peter Whelan and John D. Graham. 2014 John Wiley Sons Ltd. Published 2014 by John Wiley Sons Ltd. 170 Radiation Therapy in the Management of Prostate Cancer 171 Prior to World War II important discoveries were made in radiation science that led to new developments in .

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