tailieunhanh - Trends and methodologies of bioinformatics: Part 2

(BQ) Continued part 1, part 2 of the document Trends and methodologies of bioinformatics has contents: Basidiomycetes telomeres – A bioinformatics approach, on chip living cell microarrays for network biology, novel machine learning techniques for micro array data classification,. and other contents. Invite you to refer. | Part 5 Protein Structure Analysis 14 A Bioinformatical Approach to Study the Endosomal Sorting Complex Required for Transport ESCRT Machinery in Protozoan Parasites The Entamoeba histolytica Case Israel Lopez-Reyes1 Cecilia Banuelos1 Abigail Betanzos2 and Esther Orozco2 3 1Instituto de Ciencia y Tecnología del Distrito Federal 2Centro de Investigation y de Estudios Avanzados del Instituto Politécnico National 3Universidad Autónoma de la Ciudad de México México 1. Introduction The potential of bioinformatics for the study of protein structure and function Proteins are macromolecules formed by amino acid polymers that regulate cellular functions. Each protein is composed by the repetition and combination of 20 different amino acids whose order is determined by the genetic code. To perform their biological functions proteins fold into one or more specific spatial conformations determined by non-covalent interactions such as hydrogen bonding ionic interactions Van der Waals forces and hydrophobic packing and covalent interactions such as disulfide bonds Chiang et al. 2007 . Determining the structure and function of a protein is a milestone of many aspects of modern biology to understand its role in cell physiology. Bioinformatics is the research development or application of computational approaches for expanding the use of biological medical behavioral or health-related data. It also includes those tools to acquire store organize archive analyze or visualize infomation. Over the past years bioinformatical tools have been widely used for the prediction and study of protein biology. Moreover bioinformatical tools have revealed the existence of protein interactomes demonstrating the interaction among distinct biomolecules protein-protein protein-lipids protein-carbohydrates etc. to perform cellular processes Kuchaiev Przulj 2011 . During the last decades genome sequencing projects together with bioinformatics programs and algorithms have enormously contributed to .