tailieunhanh - Intensity modulated radiation therapy in the definitive treatment for cervical and upper thoracic esophageal cancer: Clinical outcome and acute toxicity

To evaluate patient’s characteristics and treatment outcomes of concurrent chemoradiation therapy with intensity modulated radiation therapy technique in upper third esophageal cancer patients. A descriptive perspective study on 32 upper third esophageal cancer patients treated by concurrent chemoradiation therapy with intensitymodulated radiation therapy using simultanous intergrated technique in Department of Radiation Oncology, 108 Military Central Hospital from 2014 to June 2018. | Journal of military pharmaco-medicine no1-2019 INTENSITY-MODULATED RADIATION THERAPY IN THE DEFINITIVE TREATMENT FOR CERVICAL AND UPPER-THORACIC ESOPHAGEAL CANCER: CLINICAL OUTCOME AND ACUTE TOXICITY Duong Thuy Linh1; Pham Thi Hoan1 Nguyen Van Ba1; Tran Viet Tien1 SUMMARY Objectives: To evaluate patient’s characteristics and treatment outcomes of concurrent chemoradiation therapy with intensity modulated radiation therapy technique in upper third esophageal cancer patients. Subjects and methods: A descriptive perspective study on 32 upper third esophageal cancer patients treated by concurrent chemoradiation therapy with intensitymodulated radiation therapy using simultanous intergrated technique in Department of Radiation Oncology, 108 Military Central Hospital from 2014 to June 2018. Results: Diseases were mainly seen in men, aged 40 - 59 years old. Most of the patients were in late stage. 100% histopathology was squamous cell cancer with 50% of moderately differentiation. Radiation schedules were 66 Gy/30fx and 60 Gy/28fx in 25% and 75%, respectively. Chemo 2 2 regimens were cisplatin 75 mg/m and fluorouracil 750 mg/m every 28 days. Full dose chemotherapy was given in . Complete and partial response was seen in and of patients. The 6-month, 1-year, 2-year overall survival rate was , and , respectively. Common toxicities were low hematological toxicity, esophagitis () and dermatis (). Most of them were in grade 1, 2. Conclusions: Concurrent chemoradiation with intensity-modulated radiation therapy technique in upper third esophageal cancer patients had promising results and good tolerence. * Keywords: Upper third esophageal cancer; Concurrent chemoradiotherapy; Intensity-modulated radiation therapy. INTRODUCTION Esophageal cancer ranks seventh in terms of incidence (572,000 new cases) and sixth in mortality overall (509,000 deaths). The latter signifies that esophageal cancer will be responsible for an estimated 1 .