tailieunhanh - Risk factors for radiation pneumonitis after thoracic irradiation

To investigate risk factors for radiation induced pneumonitis after thoracic irradiation in total of 378 patients including esophagus cancer (55 patients), lung cancer (137 patients), breast cancer (177 patients) and mediastinum tumor (9 patients). | Journal of military pharmaco-medicine no1-2019 RISK FACTORS FOR RADIATION PNEUMONITIS AFTER THORACIC IRRADIATION Nghiem Thi Minh Chau1; Duong Thuy Linh1; Nguyen Van Ba1 Tran Viet Tien1; Ryuji Hayashi2 SUMMARY Objectives: To investigate risk factors for radiation induced pneumonitis after thoracic irradiation in total of 378 patients including esophagus cancer (55 patients), lung cancer (137 patients), breast cancer (177 patients) and mediastinum tumor (9 patients). Subjects and methods: From January 2010 to January 2018, 378 patients with esophagus cancer, lung cancer, breast cancer, mediastinum tumor were treated with radiotherapy; these 378 cases were retrospectively analyzed for radiation induced pneumonitis. To explore the risk factors for radiation induced pneumonitis, the investigated factors include: Age, sex, subclinical interstitial lung disease, some irradiated underlying lung volumes of more than 15 Gy, 20 Gy (V15, V20), mean lung dose, some laboratory values KL-6, LDH, albumin, WBC, NEU, LYM, CRP. Results: Radiation induced pneumonitis was graded according to Common Terminology Criteria for Adverse Events v . Radiation induced pneumonitis was also found in CT-scans with or without fibrosis, the level of honey combing images involving of the lobe lung. While the relationships between not only the clinical factors but also the dosimetric factors and radiation induced pneumonitis were significantly associated, these parameters from laboratory tests showed the weak relationship with radiation induced pneumonitis. Conclusion: In our study, the clinical and dosimetric risk factors for radiation induced pneumonitis after irradiation were retrospectively investigated with mixed kinds of cancers consisted of numerous patients showed that radiation induced pneumonitis was induced more frequent in groups with increasing predictive risk factors such as over vs. below 70 years old, female vs. male, with vs. without interstitial lung disease as following .