tailieunhanh - Studying the relationship between plasma dopamine levels and clinical characteristics of bipolar disorder, manic episode

Objectives: To investigate the relationship between plasma dopamine level and clinical features in patients with bipolar disorder, manic episode. Subjects and methods: The study included 62 inpatients with bipolar disorder, manic episode, who were received treatment at National Psychiatric Hospital No 1, from July 2015 to December 2017. | Journal of military pharmaco-medicine n06-2018 STUDYING THE RELATIONSHIP BETWEEN PLASMA DOPAMINE LEVELS AND CLINICAL CHARACTERISTICS OF BIPOLAR DISORDER, MANIC EPISODE Nguyen Manh Phat*; Ngo Ngoc Tan**; Nguyen Trong Dao** SUMMARY Objectives: To investigate the relationship between plasma dopamine level and clinical features in patients with bipolar disorder, manic episode. Subjects and methods: The study included 62 inpatients with bipolar disorder, manic episode, who were received treatment at National Psychiatric Hospital No 1, from July 2015 to December 2017. Use criteria ICD-10 for diagnosis. Use method of prospective, cross-sectional, case-by-case analysis. Test plasma dopamine twice (first time in week 1, second time after first time 25 - 30 days). The data were processed by medical statistics using program STATA . Results: After a period of treatment, mean plasma dopamine levels in patients decreased significantly with p 13 ± ± p Explosive mood n = 21 ± n=2 ± p > Tensive mood n = 30 ± n=3 ± p Agitated activity n = 31 ± n=1 ± p (1: t1 - t2 = and p = ; 2: t1 - t2 = and p = ; 3: t1 - t2 = and p = ; 4: t1 - t2 = and p = ; 5: t1 - t2 = and p = ) Plasma dopamine levels in 2 surveys of hyperactivity were statistically significant differenct with p < . Plasma dopamine levels in 2 surveys of interfering in everything and hysterical activity were statistically significant differences (p < ). Table 5: Relationship between plasma dopamine levels and delusions. Plasma dopamine levels (ng/L) Statistical index Test 1 time (t1) Kind of delusion Test 2 time (t2) p1 = p2 n = 62 ( X ± SD) n = 62 ( X = SD) Delusion of persecution n = 19 ± n=0 0 0 Grandiose delusions n = 42 ± n=4 ± p < Delusion of .