tailieunhanh - Prevalence of antimicrobial resistance of neisseria gonorrhoeae in national hospital of dermatology and venereology in 2017

To describe the antimicrobial resistant levels of isolated N. gonorrhoeae. Methods: This was a cross sectional study. N. gonorrhoeae was isolated from pus or discharge of 1582 patients with urethral and/or vaginal discharge syndromes. Isolates were determined by using Gram staining, culture, and identification test, followed by antimicrobial susceptibility method. Minimum inhibitory concentration (MIC) was performed to differentiate the between resistant and susceptible isolates. | JOURNAL OF MEDICAL RESEARCH PREVALENCE OF ANTIMICROBIAL RESISTANCE OF NEISSERIA GONORRHOEAE IN NATIONAL HOSPITAL OF DERMATOLOGY AND VENEREOLOGY IN 2017 Le Van Hung, Nguyen Phuong Thuy, Le Ha Long Hai Hanoi Medical University The antimicrobial resistance of Neisseria gonorrhoeae is a complicated problem that causes many difficulties for diagnosis and treatment. Thus, more research into all aspects of antimicrobial resistance of N. gonorrhoeae is necessary. Objectives: 1. To determine the prevalence of N. gonorrhoeae infections in patients with urethral and/or vaginal discharge syndrome, who attended National Hospital of Dermatology and Venereology in 2017. 2. To describe the antimicrobial resistant levels of isolated N. gonorrhoeae. Methods: This was a cross sectional study. N. gonorrhoeae was isolated from pus or discharge of 1582 patients with urethral and/or vaginal discharge syndromes. Isolates were determined by using Gram staining, culture, and identification test, followed by antimicrobial susceptibility method. Minimum inhibitory concentration (MIC) was performed to differentiate the between resistant and susceptible isolates. Results: The prevalence of N. gonorrhoeae in patients with urethral and/or vaginal discharge syndrome was ; the isolates of N. gonorrhoeae showed resistance to ciprofloxacin (), nalidixic acid (), penicillin () and tetracycline (). N. gonorrhoeae was susceptible to spectinomycin (100%), azithromycin (), cefotaxime (), cefixime () and ceftriaxone (). As for MIC results: 7/12 isolates showed its resistance to ciprofloxacin (MIC ≥ 1 µg/ml), 7/10 to tetracycline (MIC ≥ 2 µg/ml), 5/10 to penicillin (MIC ≥ 2 µg/ml), 2/17 to ceftriaxone (MIC ≤ 0,25 µg/ml) và 100% of isolates were susceptible to spectinomycin (MIC ≤ 32 µg/ml). Conclusion: Ceftriaxone, spectinomycin, azithromycin, cefixime and cefotaxime were recommended for N. gonorrhoeae treatments while ciprofloxacin, cefuroxime, .