tailieunhanh - Production of liophilized quality control samples for several clinical chemistry test

The samples were lyophilized and tested for homogeneity and stability. Homogeneity and stability testing results for lyophilized and frozen control samples for creatinine, total cholesterol and AST showed no significant difference in 20 days across six assessment time points (p > ). The results also indicated that despite the acceptable stability performance within 20 days. The procedure for production of lyophilized quality control material for several clinical chemistry tests showed initial success. | JOURNAL OF MEDICAL RESEARCH PRODUCTION OF LIOPHILIZED QUALITY CONTROL SAMPLES FOR SEVERAL CLINICAL CHEMISTRY TEST Nguyen Quynh Giao1, Dang Quang Huy1, Pham Thi Huong Trang2, Dang Thi Ngoc Dung3, Trinh Thi Phuong Dung1 1 Faculty of Medical Technology Quality Control Center for Medical Laboratory 3 Department of Biochemistry 2 An essential part of medical laboratory quality assurance is statistical quality control (SQC) which requires the laboratory to analyse quality control materials. Our research focused on lyophilized quality control material that can be produced using materials from laboratory. Plasma samples, anticoagulated by heparin, that had common clinical chemistry parameters including creatinine, total cholesterol and AST, were collected from the Department of Medical Laboratory at the Hanoi Medical University Hospital. All parameters were within the normal reportable range. The samples were lyophilized and tested for homogeneity and stability. Homogeneity and stability testing results for lyophilized and frozen control samples for creatinine, total cholesterol and AST showed no significant difference in 20 days across six assessment time points (p > ). The results also indicated that despite the acceptable stability performance within 20 days. The procedure for production of lyophilized quality control material for several clinical chemistry tests showed initial success. Keywords: Statistical quality control, quality control material, homogeneity, stability I. INTRODUCTION Statistical quality control (SQC) - an essential part of medical laboratory quality assurance - is a procedure that requires quality control materials. Quality control materials are often commercially bought from various manufacturers at relatively high cost by laboratories. there is no Vietnamese laboratory able to selfproduce lyophilized plasma samples for Statistical quality control. The aim of this research project was to produce lyophilized quality control materials, .

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