tailieunhanh - Co-precipitation microwave assisted synthesis of Fe3O4 nanoparticles for drug delivery system

In this study, Fe3O4 magnetic nanoparticles were prepared by the co-precipitation of Fe3+ and Fe2+ with the assistant of microwave (MW) irradiation. The crystal and magnetic properties of the Fe3O4 particles obtained from different conditions of microwave reaction were examined. | Lê Thị Thu Hương và Đtg Tạp chí KHOA HỌC & CÔNG NGHỆ 190(14): 61 - 68 CO-PRECIPITATION MICROWAVE-ASSISTED SYNTHESIS OF Fe3O4 NANOPARTICLES FOR DRUG DELIVERY SYSTEM Le Thi Thu Huong1, 2, Le Mai Huong3, Tran Thi Hong Ha , Pham Hong Nam1, Ha Phuong Thu1* 3 1 Institute of Materials Science - VAST Vietnam National University of Agriculture, 3 Institute of Natural Product Chemistry - VAST 2 ABSTRACT In this study, Fe3O4 magnetic nanoparticles were prepared by the co-precipitation of Fe3+ and Fe2+ with the assistant of microwave (MW) irradiation. The crystal and magnetic properties of the Fe3O4 particles obtained from different conditions of microwave reaction were examined. The prepared magnetic nanoparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), transmission and scanning electron microscopy (TEM & SEM), X-ray powder diffraction (XRD), vibrating sample magnetometer (VSM) and Dynamic Light Scattering (DLS). After that, the optimized Fe3O4 magnetic nanoparticles (size of 10-15 nm, the saturation magnetization of 69 emu/g, and zeta potential of mV) were surface modified by alginate polymer and attached with a cancer drug Doxorubicin. The magnetic inductive heating effects and anticancer activities of the nano drug system showed that the synthesis of Fe 3O4 with microwave-assistant maintains both physical and biological properties of the material. Keywords: microwave assisted synthesis; coprecipitation; Fe3O4 nanoparticles; drug delivery system;, Doxorubicin INTRODUCTION* Fe3O4 nanoparticles have been extensively investigated for their applications in biomedicine as well as other fields. There are a variety of methods for Fe3O4 preparation reported in the literature to prepare Fe3O4 nanoparticles such as co-precipitation [1], high-power milling [2], sol-gel [3] or microfluid engineering [4]. The help of microwave in the synthesis of the Fe3O4 nanoparticles have been used in different methods due to many advantages of .