tailieunhanh - Development of therapeutic proteins: Advances and challenges

Therapeutic proteins have shown to be effective against a variety of diseases. Pharmaceutical companies are progressively focusing on research using proteins in search of novel effective therapeutics. The significant attention by researchers has resulted in considerable advances in the production and usage of therapeutic proteins in recent years. | Turkish Journal of Biology Turk J Biol (2015) 39: 343-358 © TÜBİTAK doi: Review Article Development of therapeutic proteins: advances and challenges 1,2, 3 1 1 Muhammad Sajid Hamid AKASH *, Kanwal REHMAN , Muhammad TARIQ , Shuqing CHEN Institute of Pharmacology, Toxicology, and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China 2 Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan 3 Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan 1 Received: Accepted/Published Online: Printed: Abstract: Therapeutic proteins have shown to be effective against a variety of diseases. Pharmaceutical companies are progressively focusing on research using proteins in search of novel effective therapeutics. The significant attention by researchers has resulted in considerable advances in the production and usage of therapeutic proteins in recent years. In the current study we focused on the understanding of therapeutic proteins and their impact on the human health care system. Advancements in the field of biotechnology have increased and facilitated the production of therapeutically significant proteins to combat various fatal diseases. Although proteinbased therapeutics have taken center stage in drug discovery and development and enhanced safety for human beings, certain challenges remain, including safety and immunogenicity issues, protein stability, and degradation issues. We made an attempt to discuss all possible factors that are linked with the basis of therapeutic proteins and possible challenges that are currently being faced by scientists during the development of these therapeutic proteins. Key words: Therapeutic proteins, protein classification, production of therapeutic proteins, pharmacokinetics of therapeutic .