tailieunhanh - Cancer chemopreventive effect of dietary Zataria multiflora essential oils

Zataria multiflora Boiss., with the common name Avishan-e-Shirazi, is native to Iran. This herb has been found to possess varied pharmacological properties. In the present study, for the first time, colon chemopreventive effects of Z. multiflora essential oils ( and in the diet) in rats treated with 1,2-dimethylhydrazine (DMH) were demonstrated. | Turkish Journal of Biology Turk J Biol (2014) 38: 930-939 © TÜBİTAK doi: Research Article Cancer chemopreventive effect of dietary Zataria multiflora essential oils 1, 2 3 4 Abolfazl DADKHAH *, Faezeh FATEMI , Mohammad Reza MOHAMMADI MALAYERI , Azadeh RASOOLI 1 Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran 2 Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute, Tehran, Iran 3 Department of Pathobiology, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran 4 Department of Biochemistry, Faculty of Sciences, Payame-e-Noor University, Tehran, Iran Received: Accepted: Published Online: Printed: Abstract: Zataria multiflora Boiss., with the common name Avishan-e-Shirazi, is native to Iran. This herb has been found to possess varied pharmacological properties. In the present study, for the first time, colon chemopreventive effects of Z. multiflora essential oils ( and in the diet) in rats treated with 1,2-dimethylhydrazine (DMH) were demonstrated. For this purpose, the oxidative stress/antioxidant parameters (lipid peroxidation, glutathione, superoxide dismutase, catalase, and ferric reducing ability of plasma) concomitant with xenobiotic metabolizing enzymes (CYP450 and GST) were considered. Moreover, the colonic β-catenin protein was examined in colon tissues followed by histopathological analysis. The results showed that the dietary intervention of Z. multiflora oils in tumor-bearing rats induced with DMH caused significant modulatory effects on DMH-metabolizing enzymes, but with lack of oxidative stress/antioxidant status. In parallel, the elevated protein β-catenin induced by DMH decreased significantly in treatment groups. However, the decreased tumor formations in histopathological biopsies in treated groups further confirmed these