tailieunhanh - Cancer stem cells: emerging actors in both basic and clinical cancer research

Cancer stem cells (CSCs) are a small subset of cancer cells within a tumor that are responsible for tumorigenesis and contribute to drug resistance. The CSC displays an anchorage-independent survival, active DNA-repair capacity, and relative quiescence and is capable of self-renewing and maintaining tumor growth and heterogeneity. | Turkish Journal of Biology Turk J Biol (2014) 38: 829-838 © TÜBİTAK doi: Review Article Cancer stem cells: emerging actors in both basic and clinical cancer research 1 1 2, Didem KARAKAŞ , Buse CEVATEMRE , Engin ULUKAYA * Department of Biology, Faculty of Arts and Sciences, Uludağ University, Bursa, Turkey 2 Department of Clinical Biochemistry, Faculty of Medicine, Uludağ University, Bursa, Turkey 1 Received: Accepted: Published Online: Printed: Abstract: Cancer stem cells (CSCs) are a small subset of cancer cells within a tumor that are responsible for tumorigenesis and contribute to drug resistance. The CSC displays an anchorage-independent survival, active DNA-repair capacity, and relative quiescence and is capable of self-renewing and maintaining tumor growth and heterogeneity. At the molecular level, there are several signaling pathways (., Wnt/β-catenin, Notch, and Hedgehog) to control CSC properties and alteration of these pathways has been recognized as an essential step for CSC transformation. Emerging evidence suggests that CSCs are clinically relevant. These cells are resistant to conventional chemotherapy and radiation treatment. Therefore, CSCs are thought to be the most important targets for anticancer therapy. In this review, we describe the characteristics of CSCs and how to isolate them based on some of their properties, as well as their importance in oncology. Key words: Cancer stem cell, epithelial–mesenchymal transition, niche, drug resistance, oncology 1. Introduction Over the past 50 years, many disease that cause death have dramatically decreased. Nevertheless, cancer deaths continue (Leaf, 2013). The International Agency for Research on Cancer, the specialized cancer agency of the World Health Organization, released the latest data on cancer incidence, mortality, and prevalence worldwide (Ferlay et al., 2013). According to .

• Sinh học
• Cancer stem cell
• Epithelial–mesenchymal transition
• Drug resistance
• Anchorage independent survival
• Active DNA repair capacity
• Tạp chí nghiên cứu y học
• 3D culture and analysis
• The expression of cancer stem cell markers
• Cancer stem cell markers
• Gastric cancer cell line MKN45
• Isolation of cancer stem like cells
• Hepatocellular carcinoma cell line HepG2
• Magnetic activated cell sorting
• Anti tumor drug resistant selection
• Primary evaluation
• BMC Cancer
• Mesothelioma stem cell
• RN5 EOS Puro2 cells
• Cancer cell repopulation
• Cancer stem cells
• Non small cell lung cancer
• Cell surface marker
• Cancer related lethality
• Prostate cancer differentiation
• Stromal factor PENK
• Stem cell factors
• Luminal like adenocarcinoma
• Stem like small cell carcinoma
• Differentiation marker AGR2
• Cancer associated fibroblast
• Pro tumoral inflammation molecules
• Cancer progression
• Inflammation associated cell
• Glioma stem cell
• Mesenchymal stem cell
• Cell fusion
• Glioma neovascularization
• Breast cancer
• Pathophysiological processes
• Several physiological
• Cervical cancer
• High aldehyde dehydrogenase
• Cell apoptosis
• Stem like cancer cells
• Flow cytometry
• Childhood intraocular malignant tumor
• All trans retinoic acid
• EGFR tyrosine kinase inhibitors
• Non small cell lung adenocarcinoma
• Cancer stem cell like cells
• Initiating cell
• Tumour initiation
• Disease relapse
• Ovarian carcinoma
• Platinum based therapies
• Tumor burden generated
• CYT387 treated cell derived xenografts
• Ovarian cancer
• Epithelial mesenchymal transition
• Epithelial ovarian cancer
• Stem like cells
• Salivary gland malignant neoplasms
• Head and neck squamous cell carcinoma
• CD133 monoclonal antibody
• Lv3 nanocomplex in vitro
• Cancer stem cell labeling
• Inhibition efficiency
• Cancer stem like cells
• Larynx cancer
• Tumors including lung
• Stem cell associated signaling pathways
• Hepatocellular carcinoma
• Stem cell
• Tumor initiating cell
• Human embryonic stem cells
• Early stage breast cancer
• Brest cancer stem cell
• Relapse risk score
• Hormonal therapy treatment
• Clinicopathological features
• Immunohistochemical analysis
• Colorectal cancer
• Molecular understanding
• SOX2 positive tumors
• Molecular signature
• Prognostic value
• Single leukemia stem cell
• Quiescent property
• Leukemia stem cell
• Pediatric cancer
• Germ cell tumors
• Methylation patterns
• Embryonal carcinoma
• Cervical squamous cell carcinoma
• Musashi 1
• Recurrent free survival
• Bladder cancer
• Quantitative polymerase chain reaction
• Tumor necrosis factor