tailieunhanh - Triterpenes from Celastrus hindsii Benth.
Chemical investigation of the leaves of Celastrus hindsii growing in Quang Binh, Vietnam led to the isolation and structural elucidation of three triterpenes, 3-friedelanol, 3-friedelanone and canophyllol. These structures were determined on the basis of MS and NMR spectroscopic data. | Journal of Chemistry, Vol. 45 (3), P. 373 - 376, 2007 Triterpenes from Celastrus hindsii Benth. Received 11 July 2006 Trinh Thi Thuy, Nguyen Huy Cuong, Tran Van Sung Institute of Chemistry, Vietnamese Academy of Science and Technology Summary Chemical investigation of the leaves of Celastrus hindsii growing in Quang Binh, Vietnam led to the isolation and structural elucidation of three triterpenes, 3-friedelanol, 3-friedelanone and canophyllol. These structures were determined on the basis of MS and NMR spectroscopic data. Keywords: Celastrus hindsii, celastraceae, friedelanol, friedelanone, canophyllol. I - Introduction The Celastraceae constitutes approximately 88 genera and over 1300 species of plants and are widely distributed throughout South America, China and Vietnam [1]. They have been chemically intensive studied due to many biological activities. Plant extracts of the Celastraceae have been used for centuries as insect repellents and insecticides in traditional agriculture and also for the treatment of stomach disease and cancer [1, 2]. Celastrus hindsii Benth. is a small trees growing wild or cultivated in Son La, Hoa Binh, Quang Ninh, Nam Ha, Quang Binh provinces of Vietnam. The EtOH extract of the stems from C. hindsii shows potent cytotoxicity against hepatoma, cervix carcinoma, and colon carcinoma and nasophyrnx carcinoma cells as well as against HIV replication activity in H-9 lymphocytes in vitro [2]. The crude extract of C. hindsii under the local name "Xa den" is used successfully as antitumor, anticancer agents in the Army Hospital (QY 108 Hospital, Dr. Le The Trung). Phytochemical investigation of C. hindsii was reported to contain triterpenes, sesquiterpene pyridine alkaloids as its main components [2, 3]. In our search for biological active compounds from Celastrus genus, we now report the isolation and structural determination of 3friedelanol (1), 3-friedelanone (2) and canophyllol (3). These structures were elucidated by MS and NMR .
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