tailieunhanh - Does CYP1A1 gene polymorphism affect cell damage biomarkers and ageing

This study aimed to investigate the effects of cytochrome P450 1A1 (CYP1A1) gene polymorphism on early ageing due to occupational exposure to mutagens. The project was conducted on buccal epithelial cells collected from mechanical-workshop workers and controls. | Turkish Journal of Biology Research Article Turk J Biol (2014) 38: 219-225 © TÜBİTAK doi: Does CYP1A1 gene polymorphism affect cell damage biomarkers and ageing? 1,2, 2 2 Sima Ataollahi ESHKOOR *, Patimah ISMAIL , Sabariah Abd RAHMAN 1 Institute of Gerontology, Universiti Putra Malaysia, Selangor, Malaysia 2 Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia Received: Accepted: Published Online: Printed: Abstract: This study aimed to investigate the effects of cytochrome P450 1A1 (CYP1A1) gene polymorphism on early ageing due to occupational exposure to mutagens. The project was conducted on buccal epithelial cells collected from mechanical-workshop workers and controls. Epithelial cells were obtained from the inner part of the cheeks. Techniques including comet assay, micronuclei test, realtime polymerase chain reaction, and restriction fragment length polymorphism-polymerase chain reaction were used to assess DNA damage biomarkers. The results showed that there was a significant difference in relative telomere length (P = ) between wild and mutated genotypes among all individuals. Furthermore, occupational exposure showed no statistically significant effects on biomarkers of the possible influences of gene polymorphism and different rates of ageing among workers (P > ), except for relative telomere length (P = ) among workers as a whole. It was concluded that the effects of occupational exposure to mutagens on genetic material in buccal cells mediated by CYP1A1 gene polymorphism were not significant. In addition, CYP1A1 gene polymorphism might have a protective effect against premature ageing due to occupational exposure to mutagenic chemicals. Key words: Ageing, buccal cells, CYP1A1, occupational exposure, restriction fragment length polymorphism 1. Introduction Ageing occurs via the coordinated .

• Sinh học
• Buccal cells
• Occupational exposure
• Restriction fragment length polymorphism
• Cytochrome P450 1A1
• Cytochrome P450
• BMC Veterinary Research
• Mast cells
• Pesticide exposure
• Environmental exposure
• Herbicide dichlorophenoxyacetic acid
• Nghiên cứu Cytochrome P450
• Đặc điểm cấu tạo Cytochrome P450
• Cơ chế phản ứng Cytochrome P450
• Hệ thống oxygenase ở mô động vật
• Cytochrome P450 ở vi sinh vật
• Nghiên cứu ứng dụng cytochrome P450
• Interleukin 6
• Monoclonal antibody
• Therapeutic protein–drug interaction
• Multiple cytochrome P450 enzymes
• Scientific reports
• breast cancer
• medicine
• monooxygenases
• metabolism
• Camellia sinensis L
• Kuntze
• Cytochrome P450 monooxygenase
• Molecular and in silico cloning
• Seasonal gene expression
• Nicotinamide adenine
• Binh Chau hot spring
• Thermostable enzyme
• HiSeq Illumina
• Bulk chemicals
• Food ingredient
• Luận văn Thạc sĩ
• Công nghệ thông tin
• Công nghệ nano sinh học
• Gen mã hóa cytochrome P450
• Suối nước nóng Bình Châu
• BMC Pharmacology and Toxicology
• Antimalarial drug
• Metabolic drug interaction
• Plumbaginaceae family
• Aldosterone synthase gene
• Cytochrome P450 11B2
• Mineralocorticoid receptors
• Single nucleotide polymorphism
• Coronary artery disease
• Taiwan women
• BMC Plant Biology
• Gramineae crops
• Expression regulation
• Growth and development
• Drought stress
• BMC Cancer
• Soluble epoxide hydrolase
• Epoxyeicosatrienoic acids
• Several cancer diseases
• BMC Genomics
• Intron map
• Genome wide promoter analysis
• Tissue specific promoter
• Gene duplication
• Expression profile
• Journal of Chemistry
• PEGylated quinoline
• Colon cancer
• P glycoprotein
• Cytochrome P450 enzyme
• Polyethylene glycol (PEG)
• Polymeric carriers conjugated
• NADPH cytochrome P450 reductase
• Lake Van fish
• Hydrophobic α helix transmembrane
• Methionine synthase reductase
• Chronic myeloid leukemia
• Drug metabolizing enzymes
• Glutathione S transferases
• Tyrosine kinase inhibitors
• fatty acids
• physiological roles
• Report medicine
• traditional medicine
• gastric cancer
• hormone medicine
• tumor cells
• Structural biochemistry
• oxidation
• bacteria
• CYP structure interface
• Template based modelling
• Metabolic pathways
• Three dimensional
• Metabolic ratio
• Cytochrome 2D6
• CYP2D6 gene
• báo cáo khoa học
• báo cáo y học
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• tài liệu về y học
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• medical knowledge
• medical research
• analysis of cytoplasmic