tailieunhanh - Chemical constituents of Datura metel L.

Chemical investigation of an acidic methanol extract of the whole plant of Datura metel resulted in the isolation of seven compounds, including pterodontriol B (1), disciferitriol (2), scopolamine (3), adenosine (4), thymidine (5), ilekudinoside C (6), and dioscoroside D (7). Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D NMR and mass spectra and in comparison with reported data in the literature. Among the isolated compounds, pterodontriol B, disciferitriol, ilekudinoside C, and dioscoroside D were reported for the first time from the Datura genus. | Vietnam Journal of Chemistry, International Edition, 55(2): 188-195, 2017 DOI: Chemical constituents of Datura metel L. Nguyen Thi Mai1, Nguyen Thi Cuc2, Tran Hong Quang2* 1 Hanoi University of Transport and Communications 2 Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) Received 17 October 2016; Accepted for publication 11 April 2017 Abstract Chemical investigation of an acidic methanol extract of the whole plant of Datura metel resulted in the isolation of seven compounds, including pterodontriol B (1), disciferitriol (2), scopolamine (3), adenosine (4), thymidine (5), ilekudinoside C (6), and dioscoroside D (7). Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D NMR and mass spectra and in comparison with reported data in the literature. Among the isolated compounds, pterodontriol B, disciferitriol, ilekudinoside C, and dioscoroside D were reported for the first time from the Datura genus. Keywords. Datura metel, Solanaceae, sesquiterpene, triterpenoid saponin, steroidal saponin 1. INTRODUCTION Datura metel L. is an annual herb that belongs to the Solanaceae family. It has tropical American origin and is widely cultivated in many tropical and temperate regions. In the Vietnamese traditional medicine, D. metel has been used for the treatment of coughs, bronchial asthma, and rheumatism [1]. Its leaves have been used as anesthetics in surgery, a fumigant in bronchial asthma, and anti-contractive agents in the stomach ulcers [1]. The flowers of D. metel have been used widely in the Chinese traditional medicine for the treatment of asthma, convulsions, pain, and rheumatism for centuries [2]. Previous studies of the pharmacological effects have shown that D. metel seeds exhibits a hypoglycemic activity in normal and alloxan-induced diabetic rats [3], the chloroform extract of D. metel displays an antifungal effect toward several pathogenic species of .