tailieunhanh - Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity
Malva sylvestris is traditionally used for the treatment of liver diseases, but sufficient pharmacological-based scientific literature is not available online to authenticate its use in liver ailments. We aimed to assess the hepatoprotective effects of Malva sylvestris against paracetamol-induced hepatotoxicity in mice. | Turkish Journal of Biology Turk J Biol (2014) 38: 396-402 © TÜBİTAK doi: Research Article Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity 1 1 2 2 Liaqat HUSSAIN , Javaria IKRAM , Kanwal REHMAN , Muhammad TARIQ , 3 1,2, Muhammad IBRAHIM , Muhammad Sajid Hamid AKASH * 1 College of Pharmacy, Government College University Faisalabad, Faisalabad, Pakistan 2 Institute of Pharmacology, Toxicology, and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, . China 3 Department of Applied Chemistry, Faculty of Science and Technology, Government College University Faisalabad, Faisalabad, Pakistan Received: Accepted: Published Online: Printed: Abstract: Malva sylvestris is traditionally used for the treatment of liver diseases, but sufficient pharmacological-based scientific literature is not available online to authenticate its use in liver ailments. We aimed to assess the hepatoprotective effects of Malva sylvestris against paracetamol-induced hepatotoxicity in mice. The extract was concentrated using a rotary evaporator and then desired concentrations of extracts were made by dissolving in normal saline. The standard drug silymarin (100 mg/kg) was used as a reference drug to compare the therapeutic effects of Malva sylvestris. Two different doses of Malva sylvestris (300 and 600 mg/kg) were administered intraperitoneally for 7 consecutive days followed by intraperitoneal administration of paracetamol (250 mg/kg). Paracetamol significantly induced oxidative stress in the liver, ultimately leading to increased serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, and direct bilirubin. The extract of Malva sylvestris significantly reduced the serum levels of these elevated liver enzyme markers in a .
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