tailieunhanh - Synthesis and structure of two platinum(II) complexes containing methyl eugenoxyacetate and 2-aminobenzothiazoles

Two organometallic complexes of Pt(II), trans-[PtCl2(Meteug)(Bzt)] (M1) and trans-[PtCl2(Meteug)(6-MeOBzt)] (M2) (Meteug: methyl eugenoxyacetate, Bzt: 2-aminobenzothiazole, MeOBzt: 2-amino-6-methoxybenzothiazole), have been synthesized for the first time. The structures of M1 and M2 were determined by analysis of Pt and water of hydration proportion, IR, 1H NMR and 13C NMR spectra. Meteug coordinates with Pt(II) through C=C of the allyl group in both compounds, Bzt and MeOBzt coordinate with Pt(II) via N heteroatom and at trans position compared to the allyl group. | Vietnam Journal of Chemistry, International Edition, 54(6): 667-671, 2016 DOI: Synthesis and structure of two platinum(II) complexes containing methyl eugenoxyacetate and 2-aminobenzothiazoles Nguyen Thi Thanh Chi*, Nguyen Thi Hoa Faculty of Chemistry, Hanoi National University of Education Received 30 June 2016; Accepted for publication 12 September 2016 Abstract Two organometallic complexes of Pt(II), trans-[PtCl2(Meteug)(Bzt)] (M1) and trans-[PtCl2(Meteug)(6-MeOBzt)] (M2) (Meteug: methyl eugenoxyacetate, Bzt: 2-aminobenzothiazole, MeOBzt: 2-amino-6-methoxybenzothiazole), have been synthesized for the first time. The structures of M1 and M2 were determined by analysis of Pt and water of hydration proportion, IR, 1H NMR and 13C NMR spectra. Meteug coordinates with Pt(II) through C=C of the allyl group in both compounds, Bzt and MeOBzt coordinate with Pt(II) via N heteroatom and at trans position compared to the allyl group. Keywords. Methyl eugenoxyacetate, Pt(II) complexes, 2-aminobenzothiazoles, NMR spectroscopy. 1. INTRODUCTION Since cisplatin, cis-[PtCl2(NH3)2], was appointed as a cancer chemotherapy drug for different types of cancer such as testicular or ovarian cancer, numerous Pt(II) complexes have been synthesized and examined for their antitumor activities [1, 2]. Beside their medical purpose, Pt and its complexes are known for essential roles in organic synthesis, especially many Pt-olefin complexes are intermediates in transforming olefin into more valuable compounds [3, 4]. Recently, several Pt(II) complexes with the type of K[PtCl3(olefin)], in which the used olefin is natural olefin (. safrole, methyleugenol, alkyl eugenoxyacetate) have been prepared. Based on interaction between these complexes and amines, some series of Pt(II) complexes with the structural analogs of trans-[PtCl2(olefin)(amine)] were synthesized and researched for their promising medical application [5-7]. Nevertheless, Pt(II) complexes having .