tailieunhanh - Flavonoid glycosides from Viscum album

Using combined chromatographic methods, four flavonoid glycosides, (2S)-homoeriodictyol-7-O-β-Dapiofuranosyl-(1→2)-O-β-D-glucopyranoside (1), (2S)-5-hydroxy-7,3′-dimethoxyflavanone-4′-O-β-D-apiofuranosyl- (1→2)-O-β-D-glucopyranoside (2), homoflavoyadorinin-B (3), and 3′-methoxyapiin (4) were isolated from the methanol extract of the leaves and twigs of Viscum album. Their structures were elucidated by 1D- and 2D-NMR spectra and in comparison with those reported in the literature. | Vietnam Journal of Chemistry, International Edition, 54(4): 443-447, 2016 DOI: Flavonoid glycosides from Viscum album Vu Kim Thu1, Nguyen Thi Kim Thoa1, Phan Van Kiem2* 1 Faculty of Basic Science, Hanoi University of Mining and Geology (HUMG) 2 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) Received 17 March 2016; Accepted for publication 12 August 2016 Abstract Using combined chromatographic methods, four flavonoid glycosides, (2S)-homoeriodictyol-7-O-β-Dapiofuranosyl-(1→2)-O-β-D-glucopyranoside (1), (2S)-5-hydroxy-7,3′-dimethoxyflavanone-4′-O-β-D-apiofuranosyl(1→2)-O-β-D-glucopyranoside (2), homoflavoyadorinin-B (3), and 3′-methoxyapiin (4) were isolated from the methanol extract of the leaves and twigs of Viscum album. Their structures were elucidated by 1D- and 2D-NMR spectra and in comparison with those reported in the literature. Keywords. Viscum album, flavonoid glycoside. 1. INTRODUCTION Viscum album L. var. meridianum Dans. is a hemiparasitic shrub. It has been used as a remedy in traditional oriental medicine to treat swell spleen, wound, tumour and sore ears [1]. V. album exerts several biological effects such as antitumor, anticancer [2, 3], and anti-inflammatory activities [4]. It is well established that the extract of V. album inhibited tumour angiogenesis and metastasis of haematogenous and non-haematogenous tumour cells in mice [5]. Chemical investigation of V. album proved the presence of flavonoids [6], lignans, phenylpropanoids [7], and triterpenes [8]. This paper reported the isolation and structure elucidation of four flavonoid glycosides from the methanol extract of the leaves and twigs of V. album. 2. MATERIAL AND METHODS . Plant materials The leaves and twigs of V. album were collected in Cucphuong, Ninhbinh, Vietnam in October, 2012 and identified by Prof. Dr. Ninh Khac Ban, Institute of Marine Biochemistry, VAST. A voucher specimen (TG1012) was deposited at the .