tailieunhanh - Chemical constituents of the fruits from Fissistigma oldhamii (Hemsl.) Merr. growing in Vietnam

Phytochemical studied on methanol extract of fruits Fissistigma oldhami (Hemsl.) Merr. (Annonaceae) led to the isolation of four flavonoids: 6-hydroxy-5,7,8-trimethoxy flavanone, 2’,5’-dihydroxy-3’,4’,6’-trimethoxy chalcone, quercetin, rutin and two steroids: -sitosterol (5) and -sitosterol-3-O- -D-glucopyranoside (6). The structures of the compounds were established on the basic of spectroscopic methods (UV, IR, MS, 1D-NMR and 2D-NMR) and comparison with literature data. This is first time the 6 compounds isolated from the plant. | Vietnam Journal of Chemistry, International Edition, 54(4): 467-470, 2016 DOI: Chemical constituents of the fruits from Fissistigma oldhamii (Hemsl.) Merr. growing in Vietnam Vo Cong Dung1, Nguyen Thi Quynh Giang1, Tran Dinh Thang1, Vu Dinh Hoang2* 1 Faculty of Chemistry, Vinh University 2 School of Chemical Engineering, Hanoi University of Science and Technology Received 4th July 2016; Accepted for publication 12 August 2016 Abstract Phytochemical studied on methanol extract of fruits Fissistigma oldhami (Hemsl.) Merr. (Annonaceae) led to the isolation of four flavonoids: 6-hydroxy-5,7,8-trimethoxy flavanone, 2’,5’-dihydroxy-3’,4’,6’-trimethoxy chalcone, quercetin, rutin and two steroids: -sitosterol (5) and -sitosterol-3-O- -D-glucopyranoside (6). The structures of the compounds were established on the basic of spectroscopic methods (UV, IR, MS, 1D-NMR and 2D-NMR) and comparison with literature data. This is first time the 6 compounds isolated from the plant. Keywords. Fisistigma oldhamii, Annanoceae, flavonoids, steroids. 1. INTRODUCTION Merr. in Vietnam. The genus Fissistigma (Annonaceae) consists of about 80 species, widely distributed in Australia and Asia [1]. This plant has been used as a folklore medicine for liver protection, anti-inflammatory and anti-arthritic effects, and anti-tumor action [1], [2]. F. oldhamii (Hemsl.) Merr., a member of the genus Fissistigma, is perennial shrub, 4-6 m tall or climbing shrub, 10-12 m tall [3]. In Vietnam, it is mainly distributed in Laocai, Hagiang, Caobang, Hatinh, Quangtri, Kontum, Gialai and Dongnai [3]. In the previous studies, a new aporphin alkaloid: fissoldin [4]; two cyclopentenon: stigmahamon I and stigmahamon II [5]; a new (R)-4,5-dimethoxy-3-(4′phenyl-2′-oxobutyl)-5H-furan-2-on: fissohamion [6]; a new alkaloid type of hydro-oxadiazine: fissoldhimin [7]; 11 aristolactams such as: stigmalactam, aristolactam AII, aristolactam BIII, aristolactam FII; two dioxoaporphins: .