tailieunhanh - Investigation in loading 5- fluorouracil ability of iron organic frameworks

The results showed that the MIL-53(Fe), MIL-88(Fe), and MIL-100(Fe) are capable of carrying 5-FU with capacity exceeding g/g, g/g, g/g respectively and mostly released after 10 days. The cancer cell toxicity and slow drug release ability of MIL(Fe)@5-FU were also tested by in-vitro method. Iron-organic frameworks are promising materials for cancer treatment. | Vietnam Journal of Science and Technology 56 (3B) (2018) 219-227 INVESTIGATION IN LOADING 5-FLUOROURACIL ABILITY OF IRON-ORGANIC FRAMEWORKS Hoai Phuong Nguyen Thi*, Duc Ha Ninh Institute of Chemistry and Materials, 17 Hoang Sam, Cau Giay, Ha Noi * Email: hoaiphuong1978@ Received: 16 July 2018; Accepted for publication: 7 September 2018 ABSTRACT Materials MIL-53(Fe), MIL-88(Fe) and MIL-100(Fe) have the ability to absorb many different compounds. In addition, the materials are small in size, highly bio-compatible, with no human toxicity. These materials were chosen to carry 5-fluorouracil (5-FU) for cancer treatment. Synthetic materials were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and surface characteristics (BET). 5-FU loading and releasing ability of MIL53(Fe), MIL-88(Fe) and MIL-100(Fe) have been investigated by UV-Vis spectrophotometer. The results showed that the MIL-53(Fe), MIL-88(Fe), and MIL-100(Fe) are capable of carrying 5-FU with capacity exceeding g/g, g/g, g/g respectively and mostly released after 10 days. The cancer cell toxicity and slow drug release ability of MIL(Fe)@5-FU were also tested by in-vitro method. Iron-organic frameworks are promising materials for cancer treatment. Keywords: MIL-53 (Fe), MIL-88 (Fe), MIL-100 (Fe), drug delivery, 5-FU, cancer treatment. 1. INTRODUCTION The 5-fluorouracil molecule (C4H3FN2O2) of molar mass g is relatively small. Because it contains both hydrogen bond donors and acceptors (N-H and C=O groups) it has the ability to shape co-crystals or salts after combination with other molecules, that could enhance the biological properties. 5-Fluorouracil (5-FU) is a chemotherapeutic agent employed in the treatment of several solid, such as breast, colorectal, and head and neck cancers. It has a broad spectrum of activity against various types of cancer and has a mode of action based on interfering with thymidylate synthesis. This leads to apoptosis in