tailieunhanh - Theranostic gold nanoshells: From synthesis to imaging and photothermal therapy applications

The GNSs were also bioconjugated with anti-HER2 monoclonal antibody for diagnostic breast cancer cells using dark field microscope technique. These GNS NPs play a role as nanoheaters transforming light to heat. With the present of these GNS NPs at volume density of ×1010 in chicken tissue samples, illuminated by 808 nm laser at the power density of 62 the temperature of tissue sample reachs 110˚ C after 20 minutes illumination. | Communications in Physics, Vol. 24, No. 3S2 (2014), pp. 63-70 DOI: THERANOSTIC GOLD NANOSHELLS: FROM SYNTHESIS TO IMAGING AND PHOTOTHERMAL THERAPY APPLICATIONS NGHIEM THI HA LIEN, VU THI THUY DUONG, VU DUONG, DO QUANG HOA, AND TRAN HONG NHUNG Institute of Physics, Vietnam Academy of Science and Technology E-mail: halien@ Received 20 June 2014 Accepted for publication 20 August 2014 Abstract. Gold nanoshells (GNSs) were grown on monodispersed aminoprotpyltriethoxysilane (APTES) functionalized of silica nanoparticles (NPs) cores with varying sizes ranging from 40-180 nm synthesized by Stober route. Gold shells were deposited onto the surface of silica NPs by tetrakis(hydroxymethyl) phosphonium chloride (THPC) and electroless gold plating method. The coverage of the gold nanoshells on the surfaces of the silica NPs was evaluated using UV-VIS/NIR spectrospcopy and transmission electron microscopy (TEM). The plasmon resonance wavelengths of these gold nanoshells were tunable from visible to near infrared region. The GNSs were also bioconjugated with anti-HER2 monoclonal antibody for diagnostic breast cancer cells using dark field microscope technique. These GNS NPs play a role as nanoheaters transforming light to heat. With the present of these GNS NPs at volume density of × 1010 in chicken tissue samples, illuminated by 808 nm laser at the power density of 62 the temperature of tissue sample reachs 110˚ C after 20 minutes illumination. Keywords: gold nanoshells, silica NPs, SPR, dark field image, photothermal therapy. I. INTRODUCTION Gold nanoshells typically consist of a low dielectric spherical core nanoparticle, such as silica or polystyrene, coated with a thin layer of gold whose thickness ranges from a few nanometers to tens of nanometers. GNS NPs are plasmonic materials with intense absorbing and scattering properties. The surface plasmon resonance (SPR) of GNS NPs can be fine-tuned over the visible