tailieunhanh - Emerging roles of ADAMTS metalloproteinases in regenerative medicine and restorative biology

ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteinases degrade proteoglycans and thereby have the potential to alter tissue architecture and regulate cellular function. | Turkish Journal of Biology Turk J Biol (2016) 40: 308-315 © TÜBİTAK doi: Review Article Emerging roles of ADAMTS metalloproteinases in regenerative medicine and restorative biology 1, 2 Ferah ARMUTCU *, Kadir DEMİRCAN Department of Biochemistry, Cerrahpaşa Medical Faculty, İstanbul University, Cerrahpaşa, İstanbul, Turkey 2 Department of Medical Biology, Faculty of Medicine, Turgut Özal University, Ankara, Turkey 1 Received: Accepted/Published Online: Final Version: Abstract: ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteinases degrade proteoglycans and thereby have the potential to alter tissue architecture and regulate cellular function. Recent studies about the roles of these enzymes have produced new perspectives for the molecular mechanisms behind regenerative biology with clinical potential to generate therapeutic targets to resolve tissue injury. ADAMTS enzymes play an important role in the turnover of extracellular matrix proteins in various tissues and their dysregulation has been implicated in disease-related processes such as inflammation and fibrosis. Increasing evidence indicates that they may be of key significance in the physiological and pathological central nervous system. In this review, we summarize what is currently known about the roles of ADAMTS proteins in tissue repair and regeneration as well as in the pathogenesis of other important biological processes and diseases including arthritis, atherosclerosis, and cancer. Key words: Regenerative biology, ADAMTS, extracellular matrix, nervous system, chronic disease 1. Introduction Regeneration is the process of renewal and restoration of damaged tissues with identical cells. It is also known as the ability of the cleavage of cells replacing the damaged tissues of the species ranging from bacteria to humans (Goss, 1992). In mammals, some human organs (liver and .

• Sinh học
• Regenerative biology
• Extracellular matrix
• Nervous system
• Chronic disease
• Important biological
• Stem cells
• Regenerative medicine
• Mesenchymal stem cells
• Cell biology
• Molecular biology
• Tissue engineering
• Ebook Chemical
• Functional genomic approaches
• Stem cell biology
• Embryonic stem cells
• Adult stem cells
• Protein characterization
• Biological mass spectrometry
• BMC Bioinformatics
• High throughput technologies
• Conceptual framework
• Model discovery framework
• BMC Molecular and Cell Biology
• Satellite cells
• Skeletal muscle fibers
• Regenerative potential
• Mitochondrial coupling efficiency
• Dental pulp
• Cumulative population doublings
• Cellular senescence
• Multi potency
• Genome Biology
• Induced pluripotent stem cells
• Molecular traits
• Model patient specific disease
• Cellular systems
• Liquid chromatography
• Mass spectrometry
• Regenerative therapies