tailieunhanh - Role of alternative phosphorylation and O-glycosylation of erythropoietin receptor in modulating its function: An in silico study

Detailed knowledge of the three-dimensional (3D) structure of a protein is essential for the proper understanding of its function(s) that could be modified through posttranslational modifications (PTMs). | Turkish Journal of Biology Turk J Biol (2017) 41: 816-825 © TÜBİTAK doi: Research Article Role of alternative phosphorylation and O-glycosylation of erythropoietin receptor in modulating its function: an in silico study 1, 2 3 1 4 Humera KAUSAR *, Sana GULL , Waqar AHMAD , Sana Javaid AWAN , Muhammad Tahir SARWAR , 2 5 3 2,6 Bushra IJAZ , Muhammad ANSAR , Sultan ASAD , Sajida HASSAN 1 Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan 2 Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan 3 School of Biological Sciences, University of Queensland, Australia 4 Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan 5 Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland 6 Department of Laboratory Medicine, University of Washington, Seattle, WA, USA Received: Accepted/Published Online: Final Version: Abstract: Detailed knowledge of the three-dimensional (3D) structure of a protein is essential for the proper understanding of its function(s) that could be modified through posttranslational modifications (PTMs). Among these PTMs, alterations of serine/threonine residues of a protein through phosphorylation and O-glycosylation are extremely dynamic and could modulate the functions of a protein by affecting their 3D structure. Potential of a protein for certain PTMs could be evaluated through computer-based methods. Erythropoietin (EPO) is a multifunctional protein that primarily regulates red blood cell production and is also involved in other nonhematopoietic functions; for example, EPO also has cardioprotective and neuroprotective effects. In this study, multifunctional EPO behavior has been revealed based on transient modifications of its receptor. In this study, PTMs of erythropoietin receptor (EPO-R) were predicted using .

• Sinh học
• EPO receptor
• O glycosylation
• Three dimensional structure
• Multifunctional behavior and EPO
• Posttranslational modifications
• BMC Bioinformatics
• N glycosylation
• Protein posttranslational modifications
• Molecular evolutionary analysis
• Beneficial phenotypes
• Ebook Brain behavior and epigenetics
• Brain behavior and epigenetics
• Posttranslational Histone Modifications
• Neurobiology of Psychosis
• Epigenetic regulation
• Detecting epigenetic mechanisms
• Turkish Journal of Botany
• Tạp chí Thực vật học
• Arabidopsis thaliana
• Antioxidant enzymes
• Poly(ADP ribose)ylation
• Reactive oxygen species