tailieunhanh - Insulin-mimetic biflavones from a Vietnamese medicinal plant selaginella tamariscina

All isolated compounds showed significant stimulatory effects on 2-NBDG glucose uptake in 3T3-L1 adipocyte cells. At a concentration of 10 μM, compounds 3 and 4 exhibited potential stimulatory effects by and fold of inductions as compared with the control (DMSO), respectively. The result suggests that these biflavonoids maybe potential as insulin mimetics for developing antidiabetic agents. | Vietnam Journal of Science and Technology 56 (4A) (2018) 22-29 INSULIN-MIMETIC BIFLAVONES FROM A VIETNAMESE MEDICINAL PLANT SELAGINELLA TAMARISCINA Nguyen Dinh Tuan1, 2, Nguyen Phi Hung1, 2, *, Do Huu Nghi1 1 Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Ha Noi Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Ha Noi * Email: nguyenphihung1002@ Received: 23 July 2018; Accepted for publication: 12 October 2018 ABSTRACT During the search for antidiabetic agents from natural sources, four biflavones including amentoflavone (1), robustaflavone (2), cupressuflavone (3), and 3,8′′-biapigenin (4) have been isolated from the methanol extract of Vietnamese medicinal plant Selaginella tamariscina by using combined chromatographic experiments. The chemical structures of isolated compounds were determined and elucidated by the interpretation of NMR spectral data, mass spectra as well as comparison with data from the literature. All isolated compounds showed significant stimulatory effects on 2-NBDG glucose uptake in 3T3-L1 adipocyte cells. At a concentration of 10 μM, compounds 3 and 4 exhibited potential stimulatory effects by and fold of inductions as compared with the control (DMSO), respectively. The result suggests that these biflavonoids maybe potential as insulin mimetics for developing antidiabetic agents. Keywords: Selaginella antidiabetes. tamariscina, Selaginellaceae, 2-NBDG, insulin, biflavonoids, 1. INTRODUCTION Diabetes is one of the largest global health issues of the 21st century. The number of people with diabetes anticipate rising from current estimate of 425 million in 2017, and 625 million in 2040 (IDF) [1]. Recently, a number of synthetic small molecules, such as zinc (II) complexes and vanadium compounds, have been shown to mimic the action of insulin in cell culture and animal models of diabetes. In addition,

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