tailieunhanh - Histomorphometric evaluation of the testicular parenchyma of rats submitted to protein restriction during intrauterine and postnatal life
The critical period of development is highly susceptible to disorders. Environmental contaminants, stress, and poor nutrition may permanently affect structurally and functionally an organism during adulthood. | Turkish Journal of Biology Turk J Biol (2017) 41: 428-438 © TÜBİTAK doi: Research Article Histomorphometric evaluation of the testicular parenchyma of rats submitted to protein restriction during intrauterine and postnatal life 1, 1 2 Jessica Santana de OLIVEIRA *, Alluanan Adelson do Nascimento SILVA , Sandra Lopes de SOUZA , 3 2 4 4 Rosana Nogueira de MORAIS , Elizabeth NEVES de MELO , Frederico Celso Lyra MAIA , Valdemiro Amaro da SILVA JUNIOR 1 Postgraduate Program in Animal Bioscience, Department of Veterinary Medicine, Federal Rural University of Pernambuco (UFRPE), Recife, Brazil 2 Department of Anatomy, Federal University of Pernambuco (UFPE), Recife, Brazil 3 Biological Sciences Sector, Department of Physiology, Federal University of Paraná (UFPR), Curitiba, Brazil 4 Department of Veterinary Medicine, Federal Rural University of Pernambuco (UFRPE), Recife, Brazil Received: Accepted/Published Online: Final Version: Abstract: The critical period of development is highly susceptible to disorders. Environmental contaminants, stress, and poor nutrition may permanently affect structurally and functionally an organism during adulthood. Protein restriction in intrauterine and neonatal periods may impair testicular cells and reduce steroidogenic activity. The current study investigated the effect of low protein diet during intrauterine and postnatal life on testicular function in immature and adult rats. Pregnant Wistar rats were fed either a normal protein diet or a low protein diet during pregnancy until birth and during lactation until weaning. The results showed that undernutrition during intrauterine life reduced epithelium height, tubular volume, Leydig cell volume, and serum testosterone levels, although it increased the support capacity of Sertoli cells. Tubular diameter, tubular volume, epithelium height, and Leydig cell population decreased when protein .
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