tailieunhanh - The application of mesenchymal progenitor stem cells for the reduction of oxidative stress in animals

Oxidative stress is the primary cause of lowering of the body’s immune status. It arises as a result of intense metabolic processes in humans and animals that involve a decrease in antioxidant enzymes activity at the expense of increased production of free radicals and reactive oxygen species (ROS). | Turkish Journal of Biology Turk J Biol (2017) 41: 12-19 © TÜBİTAK doi: Review Article The application of mesenchymal progenitor stem cells for the reduction of oxidative stress in animals 1, 1 2 2 1 Edyta WOJTAS *, Andrzej ZACHWIEJA , Anna ZWYRZYKOWSKA , Robert KUPCZYŃSKI , Krzysztof MARYCZ Department of Cattle Breeding and Milk Production, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland 2 Department of Environment Hygiene and Animal Welfare, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland 1 Received: Accepted/Published Online: Final Version: Abstract: Oxidative stress is the primary cause of lowering of the body’s immune status. It arises as a result of intense metabolic processes in humans and animals that involve a decrease in antioxidant enzymes activity at the expense of increased production of free radicals and reactive oxygen species (ROS). Consequently, this leads to oxidation of lipids, proteins, DNA, and RNA, causing cell proliferation reduction, faster cell aging, and subsequent degradation. Currently, there is a search for methods to maintain an oxidation– antioxidant balance. The results of many authors’ research point to the effectiveness of the use of mesenchymal stem cells (MSCs) in the treatment of various clinical disorders. Numerous studies indicate that, compared to other cells, MSCs have ability to regulate cell adhesion molecules. They also have specific immunogenic and immunosuppressive properties that determine their application in clinical research and regenerative medicine. Key words: Oxidative stress, stem cells, mesenchymal stem cells, animals, reduction 1. Introduction Every cell in both humans and livestock is involved in oxidation-reduction reactions. Their main products are oxygen free radicals, molecules having at least one unpaired electron in their structure (Betteridge, 2000; .