tailieunhanh - Biological properties of chloro salicylidene aniline and its complexes with Co(II) and Cu(II)

New complexes of chloro-salicylidene aniline with Co(II) and Cu(II) were synthesised and screened for antibacterial activity against several bacterial strains, namely Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The metal complexes showed enhanced antibacterial activity compared to uncomplexed ligands. | Turk J Biol 30 (2006) 1-4 © TÜB‹TAK Biological Properties of Chloro-salicylidene Aniline and Its Complexes with Co(II) and Cu(II) Javed IQBAL1, Syed Ahmad TIRMIZI2, Feroza Hamid WATTOO3, Muhammad IMRAN1, Muhammad Hamid Sarwar WATTOO2, Shahida SHARFUDDIN1, Shoomaila LATIF1 1 Institute of Chemistry, University of the Punjab, Lahore - PAKISTAN 2Department 3Institute of Chemistry, Quaid-i-Azam University, Islamabad - PAKISTAN of Biochemistry, University of Sindh, Jamshoro - PAKISTAN Received: Abstract: New complexes of chloro-salicylidene aniline with Co(II) and Cu(II) were synthesised and screened for antibacterial activity against several bacterial strains, namely Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The metal complexes showed enhanced antibacterial activity compared to uncomplexed ligands. Key Words: Antibacterial activity, chloro-salicylidene, metal ions Introduction Materials and Methods Various studies (1-5) have shown a relationship between the metal ions and their metal complexes as antitumour (6-8) and antibacterial agents, which is a subject of great interest. The inorganic pharmacology started to be an important field with more than 25 inorganic compounds being used in therapy as antibacterial, antiviral and anticancer drugs (8-11). All the chemicals and solvent were of analytical reagent grade. The metal(II) salts were used as their chlorides. . spectra were recorded on a Philips Analytical – PU 9800 FTIR. UV-visible spectra were obtained in methanol by Specord – 200 spectrophotometer and Acuta 710 software. Melting points were determined by digital GallenKamp apparatus. It was seen that the biological active compounds become more bacteriostatic and carcinostatic upon chelation with metal ions. Schiff bases have also attracted considerable attention in terms with their chelating abilities and analytical applications (12-14). The chlorosalicylidene aniline Schiff base is also of the same type. The aim

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• Chloro salicylidene
• Metal ions
• Antibacterial activity
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• Evaluation of antibacterial activity
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